Neus Font-Porterias1, Neus Solé-Morata1, Gerard Serra-Vidal1, Asmahan Bekada2, Karima Fadhlaoui-Zid3, Pierre Zalloua4, Francesc Calafell1, David Comas1. 1. a Departament de Ciències Experimentals i de la Salut, Institute of Evolutionary Biology (CSIC-UPF) , Universitat Pompeu Fabra , Barcelona , Spain. 2. b Département de Biotechnologie, Faculté des Sciences de la Nature et de la Vie , Université Oran 1 (Ahmad Ben Bella) , Oran , Algeria. 3. c Laboratoire de Génetique, Immunologie et Pathologies Humaines, Faculté des Sciences de Tunis , Campus Univesritaire El Manar II, Université El Manar , Tunis , Tunisia. 4. d School of Medicine, The Lebanese American University , Chouran , Beirut , Lebanon.
Abstract
BACKGROUND: The genetic composition of human North African populations is an amalgam of different ancestral components coming from the Middle East, Europe, south-Saharan Africa and autochthonous to North Africa. This complex genetic pattern is the result of migrations and admixtures in the region since Palaeolithic times. AIMS: The objective of the present study is to refine knowledge of the population history of North African populations through the analysis of complete mitochondrial sequences. SUBJECTS AND METHODS: This study has sequenced complete mitochondrial DNAs (mtDNAs) in several North African and neighbouring individuals. RESULTS: The mtDNA haplogroup classification and phylogeny shows a high genetic diversity in the region as a result of continuous admixture. The phylogenetic analysis allowed us to identify a new haplogroup characterised by positions 10 101 C and 146 C (H1v2), a sub-branch of H1v, which is restricted to North Africa and whose origins are estimated as ∼4000 years ago. CONCLUSIONS: The analysis of the complete mtDNA genome has allowed for the identification of a North African sub-lineage that might be ignored by the analysis of partial mtDNA control region sequences, highlighting the phylogeographic relevance of mtDNA complete sequence analysis.
BACKGROUND: The genetic composition of human North African populations is an amalgam of different ancestral components coming from the Middle East, Europe, south-Saharan Africa and autochthonous to North Africa. This complex genetic pattern is the result of migrations and admixtures in the region since Palaeolithic times. AIMS: The objective of the present study is to refine knowledge of the population history of North African populations through the analysis of complete mitochondrial sequences. SUBJECTS AND METHODS: This study has sequenced complete mitochondrial DNAs (mtDNAs) in several North African and neighbouring individuals. RESULTS: The mtDNA haplogroup classification and phylogeny shows a high genetic diversity in the region as a result of continuous admixture. The phylogenetic analysis allowed us to identify a new haplogroup characterised by positions 10 101 C and 146 C (H1v2), a sub-branch of H1v, which is restricted to North Africa and whose origins are estimated as ∼4000 years ago. CONCLUSIONS: The analysis of the complete mtDNA genome has allowed for the identification of a North African sub-lineage that might be ignored by the analysis of partial mtDNA control region sequences, highlighting the phylogeographic relevance of mtDNA complete sequence analysis.
Entities:
Keywords:
North Africa; Population genetics; haplogroups; mitochondrial DNA
Authors: Luísa Sá; Mafalda Almeida; Simon Azonbakin; Erica Matos; Ricardo Franco-Duarte; Alberto Gómez-Carballa; Antonio Salas; Anatóle Laleye; Alexandra Rosa; António Brehm; Martin B Richards; Pedro Soares; Teresa Rito Journal: Int J Mol Sci Date: 2022-08-16 Impact factor: 6.208
Authors: Ester Oras; Jaanika Anderson; Mari Tõrv; Signe Vahur; Riina Rammo; Sünne Remmer; Maarja Mölder; Martin Malve; Lehti Saag; Ragnar Saage; Anu Teearu-Ojakäär; Pilleriin Peets; Kristiina Tambets; Mait Metspalu; David C Lees; Maxwell V L Barclay; Martin J R Hall; Salima Ikram; Dario Piombino-Mascali Journal: PLoS One Date: 2020-01-16 Impact factor: 3.240