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Literature DB >> 29381858

Bioinorganic Explorations of Zn(II) Sequestration by Human S100 Host-Defense Proteins.

Abstract

The human innate immune system launches a metal-withholding response to starve invading microbial pathogens of essential metal nutrients. Zn(II)-sequestering proteins of the human S100 family contribute to this process and include calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/B oligomer), S100A12 (calgranulin C), and S100A7 (psoriasin). This Perspective highlights recent advances in the Zn(II) coordination chemistry of these three proteins, as well as select studies that evaluate Zn(II) sequestration as an antimicrobial mechanism.

Entities: Chemical Disease Gene Mutation Species

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Year: 2018 PMID： 29381858 PMCID： PMC5989567 DOI： 10.1021/acs.biochem.7b01305

Source DB: PubMed Journal: Biochemistry ISSN： 0006-2960 Impact factor: 3.162

76 in total

1. S100A12 provokes mast cell activation: a potential amplification pathway in asthma and innate immunity.

Authors: Zheng Yang; Wei Xing Yan; Hong Cai; Nicodemus Tedla; Chris Armishaw; Nick Di Girolamo; Hong Wei Wang; Taline Hampartzoumian; Jodie L Simpson; Peter G Gibson; John Hunt; Prue Hart; J Margaret Hughes; Michael A Perry; Paul F Alewood; Carolyn L Geczy
Journal: J Allergy Clin Immunol Date: 2006-10-06 Impact factor: 10.793

2. The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins.

Authors: Ingo P Korndörfer; Florian Brueckner; Arne Skerra
Journal: J Mol Biol Date: 2007-05-03 Impact factor: 5.469

3. Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin.

Authors: M Steinbakk; C F Naess-Andresen; E Lingaas; I Dale; P Brandtzaeg; M K Fagerhol
Journal: Lancet Date: 1990-09-29 Impact factor: 79.321

4. Calcium-dependent tetramer formation of S100A8 and S100A9 is essential for biological activity.

Authors: Nadja Leukert; Thomas Vogl; Kerstin Strupat; Rudolf Reichelt; Clemens Sorg; Johannes Roth
Journal: J Mol Biol Date: 2006-04-21 Impact factor: 5.469

5. Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis.

Authors: Derek M Gagnon; Megan Brunjes Brophy; Sarah E J Bowman; Troy A Stich; Catherine L Drennan; R David Britt; Elizabeth M Nolan
Journal: J Am Chem Soc Date: 2015-02-18 Impact factor: 15.419

6. Primary structure and binding properties of calgranulin C, a novel S100-like calcium-binding protein from pig granulocytes.

Authors: E C Dell'Angelica; C H Schleicher; J A Santomé
Journal: J Biol Chem Date: 1994-11-18 Impact factor: 5.157

7. Dual nanomolar and picomolar Zn(II) binding properties of metallothionein.

Authors: Artur Krezel; Wolfgang Maret
Journal: J Am Chem Soc Date: 2007-08-14 Impact factor: 15.419

8. Biochemical and Functional Evaluation of the Intramolecular Disulfide Bonds in the Zinc-Chelating Antimicrobial Protein Human S100A7 (Psoriasin).

Authors: Lisa S Cunden; Megan Brunjes Brophy; Grayson E Rodriguez; Hope A Flaxman; Elizabeth M Nolan
Journal: Biochemistry Date: 2017-10-19 Impact factor: 3.162

Review 9. Nutritional immunity: transition metals at the pathogen-host interface.

Authors: M Indriati Hood; Eric P Skaar
Journal: Nat Rev Microbiol Date: 2012-07-16 Impact factor: 60.633

10. Calcium-induced Tetramerization and Zinc Chelation Shield Human Calprotectin from Degradation by Host and Bacterial Extracellular Proteases.

Authors: Jules R Stephan; Elizabeth M Nolan
Journal: Chem Sci Date: 2015-11-23 Impact factor: 9.825

14 in total

Review 1. The intersection of host and fungus through the zinc lens.

Authors: Duncan Wilson; George S Deepe
Journal: Curr Opin Microbiol Date: 2019-05-24 Impact factor: 7.934

2. Initial Biochemical and Functional Evaluation of Murine Calprotectin Reveals Ca(II)-Dependence and Its Ability to Chelate Multiple Nutrient Transition Metal Ions.

Authors: Rose C Hadley; Yu Gu; Elizabeth M Nolan
Journal: Biochemistry Date: 2018-05-02 Impact factor: 3.162

3. Molecular Dynamics Investigation into the Effect of Zinc(II) on the Structure and Membrane Interactions of the Antimicrobial Peptide Clavanin A.

Authors: Searle S Duay; Gaurav Sharma; Rajeev Prabhakar; Alfredo M Angeles-Boza; Eric R May
Journal: J Phys Chem B Date: 2019-04-04 Impact factor: 2.991

4. Zinc sequestration by human calprotectin facilitates manganese binding to the bacterial solute-binding proteins PsaA and MntC.

Authors: Tomer Rosen; Rose C Hadley; Aaron T Bozzi; Daniel Ocampo; Jason Shearer; Elizabeth M Nolan
Journal: Metallomics Date: 2022-03-10 Impact factor: 4.526

5. Evolution of New Delhi metallo-β-lactamase (NDM) in the clinic: Effects of NDM mutations on stability, zinc affinity, and mono-zinc activity.

Authors: Zishuo Cheng; Pei W Thomas; Lincheng Ju; Alexander Bergstrom; Kelly Mason; Delaney Clayton; Callie Miller; Christopher R Bethel; Jamie VanPelt; David L Tierney; Richard C Page; Robert A Bonomo; Walter Fast; Michael W Crowder
Journal: J Biol Chem Date: 2018-06-16 Impact factor: 5.157

Bioinorganic Explorations of Zn(II) Sequestration by Human S100 Host-Defense Proteins.

1. S100A12 provokes mast cell activation: a potential amplification pathway in asthma and innate immunity.

2. The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins.

3. Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin.

4. Calcium-dependent tetramer formation of S100A8 and S100A9 is essential for biological activity.

5. Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis.

6. Primary structure and binding properties of calgranulin C, a novel S100-like calcium-binding protein from pig granulocytes.

7. Dual nanomolar and picomolar Zn(II) binding properties of metallothionein.

8. Biochemical and Functional Evaluation of the Intramolecular Disulfide Bonds in the Zinc-Chelating Antimicrobial Protein Human S100A7 (Psoriasin).

Review 9. Nutritional immunity: transition metals at the pathogen-host interface.

10. Calcium-induced Tetramerization and Zinc Chelation Shield Human Calprotectin from Degradation by Host and Bacterial Extracellular Proteases.

Review 1. The intersection of host and fungus through the zinc lens.

2. Initial Biochemical and Functional Evaluation of Murine Calprotectin Reveals Ca(II)-Dependence and Its Ability to Chelate Multiple Nutrient Transition Metal Ions.

3. Molecular Dynamics Investigation into the Effect of Zinc(II) on the Structure and Membrane Interactions of the Antimicrobial Peptide Clavanin A.

4. Zinc sequestration by human calprotectin facilitates manganese binding to the bacterial solute-binding proteins PsaA and MntC.

5. Evolution of New Delhi metallo-β-lactamase (NDM) in the clinic: Effects of NDM mutations on stability, zinc affinity, and mono-zinc activity.

Review 6. H₂S and reactive sulfur signaling at the host-bacterial pathogen interface.

7. Avian MRP126 Restricts Microbial Growth through Ca(II)-Dependent Zn(II) Sequestration.

8. Calcium Regulates S100A12 Zinc Sequestration by Limiting Structural Variations.

9. Antimicrobial action of calprotectin that does not involve metal withholding.

Review 10. Molecular Evolution of Transition Metal Bioavailability at the Host-Pathogen Interface.

Review 9. Nutritional immunity: transition metals at the pathogen-host interface.

Review 1. The intersection of host and fungus through the zinc lens.

Review 6. H2S and reactive sulfur signaling at the host-bacterial pathogen interface.

Review 10. Molecular Evolution of Transition Metal Bioavailability at the Host-Pathogen Interface.

Review 6. H₂S and reactive sulfur signaling at the host-bacterial pathogen interface.