Daniel Wilhelms1, Folke Sjöberg, Michelle Chew. 1. From the Division of Drug Research, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University (DW), Department of Emergency Medicine, Local Health Care Services in Central Östergötland, Region Östergötland (DW), Division of Surgery, Orthopaedics and Oncology, Department of Clinical and Experimental Medicine, Linköping University (FS), Department of Hand and Plastic Surgery, Anaesthetics, Operations and Specialty Surgery Center, Region Östergötland (FS), Division of Drug Research, Department of Medical and Health Sciences, Linköping University (MC) and Department of Anaesthesiology and Intensive Care in Linköping, Anaesthetics, Operations and Specialty Surgery Center, Region Östergötland, Linköping, Sweden (MC).