| Literature DB >> 29381357 |
Fakir Shahidullah Tareq1,2, Choudhury Mahmood Hasan3, M Mukhlesur Rahman4, Mohd Mukrish Mohd Hanafi5, Lucio Colombi Ciacchi6, Monika Michaelis6, Tilmann Harder7,8, Jan Tebben8, Md Tofazzal Islam9, Peter Spiteller1.
Abstract
Three new and seven known calopins were isolated from Caloboletus radicans. The structures of the new cyclocalopins, 8-deacetylcyclocalopin B (1), cyclocalopin A-15-ol (2), and 12,15-dimethoxycyclocalopin A (3), were mainly elucidated by NMR and MS data analysis. The stereochemistry of 1-3 was assigned based on NOE correlations and coupling constants and by comparison of their CD spectra with those of similar known calopins. While 1-10 were inactive against two cancer cell lines, they displayed anti-staphylococcal activity against methicillin-resistant Staphylococcus aureus strains (MRSA) with MIC values of 16-256 μg/mL. Moreover, some calopins were active against the fish pathogen Enterococcus faecalis F1B1.Entities:
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Year: 2018 PMID： 29381357 DOI： 10.1021/acs.jnatprod.7b00525
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050