| Literature DB >> 29380947 |
Oxana Semyachkina-Glushkovskaya1, Vladimir Chehonin2, Ekaterina Borisova1,3, Ivan Fedosov1,4, Anton Namykin1,4, Arkady Abdurashitov1,4, Alexander Shirokov1,5,6, Boris Khlebtsov5, Yelena Lyubun5, Nikita Navolokin1,6, Mariya Ulanova1, Natalia Shushunova1, Alexander Khorovodov1, Ilana Agranovich1, Anastasia Bodrova1, Madina Sagatova1, Ali Esmat Shareef1, Elena Saranceva1, Tatyana Iskra1, Mariya Dvoryatkina1, Ekaterina Zhinchenko1, Olga Sindeeva1, Valery Tuchin4,7,8, Jurgen Kurths1,9,10.
Abstract
A new application of the photodynamic treatment (PDT) is presented for the opening of blood-brain barrier (BBB) and the brain clearing activation that is associated with it, including the use of gold nanoparticles as emerging photosensitizer carriers in PDT. The obtained results clearly demonstrate 2 pathways for the brain clearing: (1) using PDT-opening of BBB and intravenous injection of FITC-dextran we showed a clearance of this tracer via the meningeal lymphatic system in the subdural space; (2) using optical coherence tomography and intraparenchymal injection of gold nanorods, we observed their clearance through the exit gate of cerebral spinal fluid from the brain into the deep cervical lymph node, where the gold nanorods were accumulated. These data contribute to a better understanding of the cerebrovascular effects of PDT and shed light on mechanisms, underlying brain clearing after PDT-related opening of BBB, including clearance from nanoparticles as drug carriers.Entities:
Keywords: blood-brain barrier; cerebral lymphatic vessels; gold nanorods; optical coherence tomography; photodynamic treatment
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Year: 2018 PMID： 29380947 DOI： 10.1002/jbio.201700287
Source DB: PubMed Journal: J Biophotonics ISSN： 1864-063X Impact factor: 3.207