J-H Kim1, Y Lee. 1. Yunhwan Lee, MD, DrPH, Department of Preventive Medicine and Public Health, Ajou University School of Medicine, 164 World cup-ro, Youngtong-gu, Suwon 16499, Korea, Tel: +82-31-219-5085; Fax: +82-31-219-5084; E-mail: yhlee@ajou.ac.kr.
Abstract
OBJECTIVES: To investigate the association between stroke and incident dementia in the presence of a competing risk of death. METHODS: This study used the National Health Insurance Service-Senior (NHIS-Senior) claim database from 2002 to 2013 (n = 22,792). Stroke (I69.0-I69.9) and dementia (F01-F03, G30, G31.1) patients were defined by the International Classification of Disease 10th revision. The association of stroke with dementia or death was assessed with Cox proportional hazards model and competing-risk model. RESULTS: During the 10-year follow-up period, there were 1,307 dementia events (5.7%) and 9,272 deaths (40.7%). In the Cox model, the adjusted hazard ratio (HR) for dementia was 2.37 times higher in those who experienced strokes, compared with the non-stroke group (95% CI: 2.23, 2.51). In the presence of death as competing event, stroke was associated with an elevated dementia incidence (HR = 2.06, 95% CI: 1.92, 2.20). CONCLUSION: Stroke was significantly associated with an increased risk of incident dementia, with the magnitude of the association being attenuated in the competing risk model.
OBJECTIVES: To investigate the association between stroke and incident dementia in the presence of a competing risk of death. METHODS: This study used the National Health Insurance Service-Senior (NHIS-Senior) claim database from 2002 to 2013 (n = 22,792). Stroke (I69.0-I69.9) and dementia (F01-F03, G30, G31.1) patients were defined by the International Classification of Disease 10th revision. The association of stroke with dementia or death was assessed with Cox proportional hazards model and competing-risk model. RESULTS: During the 10-year follow-up period, there were 1,307 dementia events (5.7%) and 9,272 deaths (40.7%). In the Cox model, the adjusted hazard ratio (HR) for dementia was 2.37 times higher in those who experienced strokes, compared with the non-stroke group (95% CI: 2.23, 2.51). In the presence of death as competing event, stroke was associated with an elevated dementia incidence (HR = 2.06, 95% CI: 1.92, 2.20). CONCLUSION:Stroke was significantly associated with an increased risk of incident dementia, with the magnitude of the association being attenuated in the competing risk model.
Authors: N K J Oksala; H Jokinen; S Melkas; A Oksala; T Pohjasvaara; M Hietanen; R Vataja; M Kaste; P J Karhunen; T Erkinjuntti Journal: J Neurol Neurosurg Psychiatry Date: 2009-07-19 Impact factor: 10.154
Authors: K Narasimhalu; S Ang; D A De Silva; M-C Wong; H-M Chang; K-S Chia; A P Auchus; C Chen Journal: Neurology Date: 2009-12-01 Impact factor: 9.910
Authors: Renata M Sousa; Cleusa P Ferri; Daisy Acosta; Emiliano Albanese; Mariella Guerra; Yueqin Huang; K S Jacob; A T Jotheeswaran; Juan J Llibre Rodriguez; Guillermina Rodriguez Pichardo; Marina Calvo Rodriguez; Aquiles Salas; Ana Luisa Sosa; Joseph Williams; Tirso Zuniga; Martin Prince Journal: Lancet Date: 2009-11-28 Impact factor: 79.321
Authors: Elżbieta Kuźma; Ilianna Lourida; Sarah F Moore; Deborah A Levine; Obioha C Ukoumunne; David J Llewellyn Journal: Alzheimers Dement Date: 2018-08-31 Impact factor: 21.566
Authors: Marzena Ułamek-Kozioł; Stanisław Jerzy Czuczwar; Sławomir Januszewski; Ryszard Pluta Journal: Int J Mol Sci Date: 2020-01-30 Impact factor: 5.923
Authors: Marzena Ułamek-Kozioł; Stanisław J Czuczwar; Janusz Kocki; Sławomir Januszewski; Jacek Bogucki; Anna Bogucka-Kocka; Ryszard Pluta Journal: J Alzheimers Dis Date: 2019 Impact factor: 4.472
Authors: Ryszard Pluta; Marzena Ułamek-Kozioł; Janusz Kocki; Jacek Bogucki; Sławomir Januszewski; Anna Bogucka-Kocka; Stanisław J Czuczwar Journal: Mol Neurobiol Date: 2019-11-12 Impact factor: 5.682