Jennifer Tan1, Ana Pina2, João Borges-Costa2,3,4. 1. 1 CUF Sintra, Mem Martins, Sintra, Portugal. 2. 2 Clínica Universitária de Dermatologia de Lisboa, Hospital de Santa Maria, Lisboa, Portugal. 3. 3 Faculdade de Medicina da Universidade de Lisboa, Unidade de Investigação em Dermatologia, Lisboa, Portugal. 4. 4 Instituto de Higiene e Medicina Tropical, Lisboa, Portugal.
Abstract
BACKGROUND: With the increasing number of HIV-infected patients receiving highly active antiretroviral therapy (HAART), the shift in their dermatologic profile becomes less characteristic of AIDS-defining illnesses. METHODS: Retrospective review of mucocutaneous pathology among patients seen at HIV-Dermatology Clinic from January 2009 to December 2013. RESULTS: Among 534 patients, there were 68.4% males and 31.6% females, with 8.7-year average duration of infection; 82.8% were receiving HAART. Kaposi sarcoma was the only relatively frequent AIDS-defining disease. Fungal and viral infections were common, with human papilloma virus (HPV) as the most frequent overall. Benign and premalignant tumors were associated with HAART and CD4 >200/mm3 ( P < .05). Psoriasis was prevalent among patients without HAART ( P < .05). Prurigo was associated with lower CD4 count ( P < .001). CONCLUSION: Patients receiving HAART are faced with chronic skin problems such as benign and premalignant tumors, and HPV infection adds to their neoplastic predisposition. Further research is recommended to develop protocols for treating psoriasis and screening for HPV-associated neoplasia among patients.
BACKGROUND: With the increasing number of HIV-infectedpatients receiving highly active antiretroviral therapy (HAART), the shift in their dermatologic profile becomes less characteristic of AIDS-defining illnesses. METHODS: Retrospective review of mucocutaneous pathology among patients seen at HIV-Dermatology Clinic from January 2009 to December 2013. RESULTS: Among 534 patients, there were 68.4% males and 31.6% females, with 8.7-year average duration of infection; 82.8% were receiving HAART. Kaposi sarcoma was the only relatively frequent AIDS-defining disease. Fungal and viral infections were common, with human papilloma virus (HPV) as the most frequent overall. Benign and premalignant tumors were associated with HAART and CD4 >200/mm3 ( P < .05). Psoriasis was prevalent among patients without HAART ( P < .05). Prurigo was associated with lower CD4 count ( P < .001). CONCLUSION:Patients receiving HAART are faced with chronic skin problems such as benign and premalignant tumors, and HPV infection adds to their neoplastic predisposition. Further research is recommended to develop protocols for treating psoriasis and screening for HPV-associated neoplasia among patients.
Authors: Pedro C Queiroz Zancanaro; Laura Y McGirt; Adam J Mamelak; Ruby H-N Nguyen; Ciro R Martins Journal: J Am Acad Dermatol Date: 2006-02-23 Impact factor: 11.527
Authors: Jennifer Beecker; Curtis Cooper; Mark G Kirchhof; Anton L Pozniak; Juergen K Rockstroh; Kim A Papp; Jan P Dutz; Melinda J Gooderham; Robert Gniadecki; Chih-Ho Hong; Charles W Lynde; Catherine Maari; Yves Poulin; Ronald B Vender; Sharon L Walmsley Journal: Dermatol Ther (Heidelb) Date: 2022-04-21