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Literature DB >> 29380605

Click, Release, and Fluoresce: A Chemical Strategy for a Cascade Prodrug System for Codelivery of Carbon Monoxide, a Drug Payload, and a Fluorescent Reporter.

Ladie Kimberly C De La Cruz¹, Stéphane L Benoit², Zhixiang Pan¹, Bingchen Yu¹, Robert J Maier², Xingyue Ji¹, Binghe Wang¹.

Abstract

A chemical strategy was developed wherein a single trigger sets in motion a three-reaction cascade leading to the release of more than one drug-component in sequence with the generation of a fluorescent side product for easy monitoring. As a proof of concept, codelivery of CO with the antibiotic metronidazole was demonstrated.

Entities: Chemical

Mesh：

Substances：

Year: 2018 PMID： 29380605 DOI： 10.1021/acs.orglett.7b03348

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

13 in total

1. H₂S donors with optical responses.

Authors: Michael D Pluth; Yu Zhao; Matthew M Cerda
Journal: Methods Enzymol Date: 2020-06-15 Impact factor: 1.600

2. Tracking CO release in cells via the luminescence of donor molecules and/or their by-products.

Authors: Tatiana Soboleva; Lisa M Berreau
Journal: Isr J Chem Date: 2019-02-11 Impact factor: 3.333

Review 3. Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response.

Authors: Zhengnan Yuan; Ladie Kimberly De La Cruz; Xiaoxiao Yang; Binghe Wang
Journal: Pharmacol Rev Date: 2022-07 Impact factor: 18.923

Click, Release, and Fluoresce: A Chemical Strategy for a Cascade Prodrug System for Codelivery of Carbon Monoxide, a Drug Payload, and a Fluorescent Reporter.

1. H₂S donors with optical responses.

2. Tracking CO release in cells via the luminescence of donor molecules and/or their by-products.

Review 3. Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response.

Review 4. "CO in a pill": Towards oral delivery of carbon monoxide for therapeutic applications.

5. Towards "CO in a pill": Pharmacokinetic studies of carbon monoxide prodrugs in mice.

6. Development of Triggerable, Trackable, and Targetable Carbon Monoxide Releasing Molecules.

Review 7. Carbon monoxide: An emerging therapy for acute kidney injury.

Review 8. Carbon Monoxide and Nitric Oxide as Examples of the Youngest Class of Transmitters.

9. Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles.

Review 10. Nature's marvels endowed in gaseous molecules I: Carbon monoxide and its physiological and therapeutic roles.

Click, Release, and Fluoresce: A Chemical Strategy for a Cascade Prodrug System for Codelivery of Carbon Monoxide, a Drug Payload, and a Fluorescent Reporter.

1. H2S donors with optical responses.

2. Tracking CO release in cells via the luminescence of donor molecules and/or their by-products.

Review 3. Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response.

Review 4. "CO in a pill": Towards oral delivery of carbon monoxide for therapeutic applications.

5. Towards "CO in a pill": Pharmacokinetic studies of carbon monoxide prodrugs in mice.

6. Development of Triggerable, Trackable, and Targetable Carbon Monoxide Releasing Molecules.

Review 7. Carbon monoxide: An emerging therapy for acute kidney injury.

Review 8. Carbon Monoxide and Nitric Oxide as Examples of the Youngest Class of Transmitters.

9. Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles.

Review 10. Nature's marvels endowed in gaseous molecules I: Carbon monoxide and its physiological and therapeutic roles.

1. H₂S donors with optical responses.