Literature DB >> 29380353

Regenerative Solutions for Inherited Diseases.

Jakub Tolar1.   

Abstract

It is clear that regenerative medicine therapies will dominate the future landscape, particularly for genetic disorders and other diseases that have been proven intractable with current therapies. As we explore unique combinations of rapidly emerging fields-from computational biology to genome editing to molecular therapeutics-the past goal of ameliorating symptoms of disease is rapidly giving way to the goal of restoring a patient to health and normal function.
© 2018 American Society for Clinical Pharmacology and Therapeutics.

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Year:  2018        PMID: 29380353      PMCID: PMC9309030          DOI: 10.1002/cpt.990

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN: 0009-9236            Impact factor:   6.903


  5 in total

Review 1.  Alternative donor transplant of benign primary hematologic disorders.

Authors:  J Tolar; P Sodani; H Symons
Journal:  Bone Marrow Transplant       Date:  2015-02-09       Impact factor: 5.483

2.  CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein.

Authors:  Lichun Tang; Yanting Zeng; Hongzi Du; Mengmeng Gong; Jin Peng; Buxi Zhang; Ming Lei; Fang Zhao; Weihua Wang; Xiaowei Li; Jianqiao Liu
Journal:  Mol Genet Genomics       Date:  2017-03-01       Impact factor: 3.291

3.  Translating genome engineering to better clinical outcomes.

Authors:  Jakub Tolar
Journal:  Transl Res       Date:  2013-02-15       Impact factor: 7.012

Review 4.  Gene editing and its application for hematological diseases.

Authors:  Mark J Osborn; Joseph J Belanto; Jakub Tolar; Daniel F Voytas
Journal:  Int J Hematol       Date:  2016-05-27       Impact factor: 2.490

5.  A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.

Authors:  Martin Jinek; Krzysztof Chylinski; Ines Fonfara; Michael Hauer; Jennifer A Doudna; Emmanuelle Charpentier
Journal:  Science       Date:  2012-06-28       Impact factor: 47.728

  5 in total

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