| Literature DB >> 29380304 |
Thomas Prates Ong1, Paul C Guest2.
Abstract
Developmental programming resulting from maternal malnutrition can lead to an increased risk of metabolic disorders such as obesity, insulin resistance, type 2 diabetes and cardiovascular disorders in the offspring in later life. Furthermore, many conditions linked with developmental programming are also known to be associated with the aging process. This review summarizes the available evidence about the molecular mechanisms underlying these effects, with the potential to identify novel areas of therapeutic intervention. This could also lead to the discovery of new treatment options for improved patient outcomes.Entities:
Keywords: Aging; Developmental programming; Diabetes; Metabolic disease; Novel therapeutics; Obesity
Mesh:
Substances:
Year: 2018 PMID: 29380304 DOI: 10.1007/978-1-4939-7614-0_1
Source DB: PubMed Journal: Methods Mol Biol ISSN: 1064-3745