Gilles Barone-Rochette1,2,3, Feras Zoreka4, Loïc Djaileb5, Nicolas Piliero4, Alex Calizzano5, Jean Louis Quesada6, Alexis Broisat7, Laurent Riou7, Jacques Machecourt4, Daniel Fagret7,5, Gerald Vanzetto4,7,8, Catherine Ghezzi7. 1. Department of Cardiology, University Hospital, Grenoble Alpes, France. GBarone@chu-grenoble.fr. 2. INSERM U1039, Bioclinic Radiopharmaceutics Laboratory, Grenoble Alpes, France. GBarone@chu-grenoble.fr. 3. French Alliance Clinical Trial, French Clinical Research Infrastructure Network, Paris, France. GBarone@chu-grenoble.fr. 4. Department of Cardiology, University Hospital, Grenoble Alpes, France. 5. Department of Nuclear medicine, University Hospital, Grenoble Alpes, France. 6. Center of Clinical Investigations, Grenoble Alpes University Hospital, Grenoble, France. 7. INSERM U1039, Bioclinic Radiopharmaceutics Laboratory, Grenoble Alpes, France. 8. French Alliance Clinical Trial, French Clinical Research Infrastructure Network, Paris, France.
Abstract
BACKGROUND: The aim of this study was to determine the diagnostic accuracy of stress thallium-201/rest technetium-99m-sestamibi sequential dual-isotope high-speed myocardial perfusion imaging (DI-HS-MPI) against invasively determined fractional flow reserve (FFR). METHODS: Fifty-four consecutive patients prospectively underwent DI-HS-MPI before invasive coronary angiography. Perfusion was scored visually by summed stress score on a patient and coronary territory basis. Significant coronary artery disease (CAD) was defined by the presence of ≥ 90% stenosis/occlusion or fractional flow reserve ≤ 0.80 for coronary stenosis ≥ 50%. RESULTS: FFR was measured in 69 of 162 coronary vessels, with 1.28 ± 0.56 vessels assessed/patient. Sensitivity, specificity, and diagnostic accuracy of MPI for the detection of significant CAD were 92.8%, 69.2%, and 81.4%, on a patient basis, and 83.7%, 90.4%, and 88.8% by coronary territory. CONCLUSIONS: DI-HS-MPI accurately detects functionally significant CAD as defined by using FFR.
BACKGROUND: The aim of this study was to determine the diagnostic accuracy of stress thallium-201/rest technetium-99m-sestamibi sequential dual-isotope high-speed myocardial perfusion imaging (DI-HS-MPI) against invasively determined fractional flow reserve (FFR). METHODS: Fifty-four consecutive patients prospectively underwent DI-HS-MPI before invasive coronary angiography. Perfusion was scored visually by summed stress score on a patient and coronary territory basis. Significant coronary artery disease (CAD) was defined by the presence of ≥ 90% stenosis/occlusion or fractional flow reserve ≤ 0.80 for coronary stenosis ≥ 50%. RESULTS: FFR was measured in 69 of 162 coronary vessels, with 1.28 ± 0.56 vessels assessed/patient. Sensitivity, specificity, and diagnostic accuracy of MPI for the detection of significant CAD were 92.8%, 69.2%, and 81.4%, on a patient basis, and 83.7%, 90.4%, and 88.8% by coronary territory. CONCLUSIONS:DI-HS-MPI accurately detects functionally significant CAD as defined by using FFR.
Entities:
Keywords:
Coronary artery disease; SPECT; dual isotope; fractional flow reserve; new camera CZT
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