Yu-Wen Huang1,2, Ying-Ju Kuo2,3, Ching-Yin Ho4,5,6, Ming-Ying Lan7,8. 1. Department of Otolaryngology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, Taiwan, Republic of China. 2. School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China. 3. Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China. 4. Department of Otolaryngology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, Taiwan, Republic of China. tigertpe@gmail.com. 5. School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China. tigertpe@gmail.com. 6. Department of Otolaryngology, Cheng Hsin General Hospital, Taipei, Taiwan, Republic of China. tigertpe@gmail.com. 7. Department of Otolaryngology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei, Taiwan, Republic of China. mingyinglan@gmail.com. 8. School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China. mingyinglan@gmail.com.
Abstract
INTRODUCTION: Seromucinous hamartoma (SH) is a rare benign glandular proliferation of the sinonasal tract and nasopharynx. Only few cases have been reported in recent years. MATERIALS AND METHODS: We performed a retrospective medical record review of seven patients diagnosed with sinonasal SH who underwent endoscopic endonasal surgery. RESULTS: There were 5 males and 2 females, ranged in age from 40 to 98 years (mean 60 years, SD ± 18.9). Two lesions arise from middle turbinate, two from uncinate process, and 3 (but 4 specimens) from nasal septum. Pathological features revealed a polypoid lesion with submucosal proliferation of seromucinous glands arranged in lobular and haphazard patterns. In immunohistochemical study, the seromucinous glands of SH were reactive for cytokeratin, including CK7, CK19, HMWK, but negative for CK20. CONCLUSION: Sinonasal SH is a rare diagnosis characterized by a polypoid lesion with a haphazard proliferation of seromucinous glands. The rhinologists should consider it in the differential diagnosis of a polypoid lesion in the nasal cavity.
INTRODUCTION:Seromucinous hamartoma (SH) is a rare benign glandular proliferation of the sinonasal tract and nasopharynx. Only few cases have been reported in recent years. MATERIALS AND METHODS: We performed a retrospective medical record review of seven patients diagnosed with sinonasal SH who underwent endoscopic endonasal surgery. RESULTS: There were 5 males and 2 females, ranged in age from 40 to 98 years (mean 60 years, SD ± 18.9). Two lesions arise from middle turbinate, two from uncinate process, and 3 (but 4 specimens) from nasal septum. Pathological features revealed a polypoid lesion with submucosal proliferation of seromucinous glands arranged in lobular and haphazard patterns. In immunohistochemical study, the seromucinous glands of SH were reactive for cytokeratin, including CK7, CK19, HMWK, but negative for CK20. CONCLUSION: Sinonasal SH is a rare diagnosis characterized by a polypoid lesion with a haphazard proliferation of seromucinous glands. The rhinologists should consider it in the differential diagnosis of a polypoid lesion in the nasal cavity.
Authors: Jivianne T Lee; Rohit Garg; Joseph Brunworth; David B Keschner; Lester D R Thompson Journal: Am J Rhinol Allergy Date: 2013 Jul-Aug Impact factor: 2.467