AIM: The aim of this study was to assess the influence of intraoperative cytokine adsorption on the perioperative vasoplegia, inflammatory response and outcome during orthotopic heart transplantation (OHT). METHODS: Eighty-four OHT patients were separated into the cytokine adsorption (CA)-treated group or controls. Vasopressor demand, inflammatory response described by procalcitonin and C-reactive protein, and postoperative outcome were assessed performing propensity score matching. RESULTS: In the 16 matched pairs, the median noradrenaline requirement was significantly less in the CA-treated patients than in the controls on the first and second postoperative days (0.14 vs 0.3 μg*kg-1 *min-1 , P = .039 and 0.06 vs 0.32 μg*kg-1 *min-1 , P = .047). The inflammatory responses were similar in the two groups. There was a trend toward shorter length of mechanical ventilation and intensive care unit (ICU) stay in the CA-treated group compared to the controls. No difference in adverse events was observed between the two groups. The frequency of renal replacement therapy was less in the CA‐treated patients than in the controls. CONCLUSIONS: Intraoperative CA treatment was associated with reduced vasopressor demand with a favorable tendency in length of mechanical ventilation, ICU stay and renal replacement therapy. CA treatment was not linked to higher rates of adverse events.
AIM: The aim of this study was to assess the influence of intraoperative cytokine adsorption on the perioperative vasoplegia, inflammatory response and outcome during orthotopic heart transplantation (OHT). METHODS: Eighty-four OHT patients were separated into the cytokine adsorption (CA)-treated group or controls. Vasopressor demand, inflammatory response described by procalcitonin and C-reactive protein, and postoperative outcome were assessed performing propensity score matching. RESULTS: In the 16 matched pairs, the median noradrenaline requirement was significantly less in the CA-treated patients than in the controls on the first and second postoperative days (0.14 vs 0.3 μg*kg-1 *min-1 , P = .039 and 0.06 vs 0.32 μg*kg-1 *min-1 , P = .047). The inflammatory responses were similar in the two groups. There was a trend toward shorter length of mechanical ventilation and intensive care unit (ICU) stay in the CA-treated group compared to the controls. No difference in adverse events was observed between the two groups. The frequency of renal replacement therapy was less in the CA‐treated patients than in the controls. CONCLUSIONS: Intraoperative CA treatment was associated with reduced vasopressor demand with a favorable tendency in length of mechanical ventilation, ICU stay and renal replacement therapy. CA treatment was not linked to higher rates of adverse events.
Authors: Elettra C Poli; Lorenzo Alberio; Anna Bauer-Doerries; Carlo Marcucci; Aurélien Roumy; Matthias Kirsch; Eleonora De Stefano; Lucas Liaudet; Antoine G Schneider Journal: Crit Care Date: 2019-04-03 Impact factor: 9.097
Authors: David Santer; Jules Miazza; Luca Koechlin; Brigitta Gahl; Bejtush Rrahmani; Alexa Hollinger; Friedrich S Eckstein; Martin Siegemund; Oliver T Reuthebuch Journal: J Clin Med Date: 2021-02-03 Impact factor: 4.241
Authors: Thomas Köhler; Elke Schwier; Janina Praxenthaler; Carmen Kirchner; Dietrich Henzler; Claas Eickmeyer Journal: Int J Mol Sci Date: 2021-11-26 Impact factor: 5.923
Authors: Muharrem Akin; Vera Garcheva; Jan-Thorben Sieweke; Ulrike Flierl; Hannah C Daum; Johann Bauersachs; Andreas Schäfer Journal: PLoS One Date: 2020-11-03 Impact factor: 3.240