| Literature DB >> 29376944 |
Ethan R Stewart1, George R Thompson2,3.
Abstract
The authors of the published paper [1] would like to correct Table 1.[...].Entities:
Year: 2016 PMID: 29376944 PMCID: PMC5715935 DOI: 10.3390/jof2040027
Source DB: PubMed Journal: J Fungi (Basel) ISSN: 2309-608X
Treatment recommendations for invasive aspergillosis.
| Recommendation | Drug | Dosing | Comments |
|---|---|---|---|
| Primary | Voriconazole | 6 mg/kg IV every 12 h times two then 4 mg/kg IV every 12 h | Oral therapy at mg/kg dosing or 200–300 mg every 12 h; TDM required |
| Alternatives | Lipsosomal amphotericin B (L-AMB) | 3–5 mg/kg/day IV | |
| Isavuconazole | 200 mg every 8 h IV or PO times six then 200 mg daily IV or PO | Need for TDM remains undefined | |
| Voriconazole plus Anidulafungin | Vorizonazole as above plus Anidulafungin 200 mg IV daily times one then 100 mg IV daily | Combination therapy considered in severe disease and with hematologic malignancy | |
| Amphotericin B Lipid Complex (ABLC) | 5 mg/kg/day IV | ||
| Secondary | Caspofungin | 70 mg IV daily times one then 50 mg IV daily | Monotherapy as salvage |
| Posaconazole | Oral suspension: 200 mg PO every 8 h, Tablet: 300 mg PO every 12 h times two then 300 mg PO daily, Intravenous: 300 mg IV every 12 h times two then 300 mg IV daily | Caution in use of tablet formulation with acid suppression; TDM required | |
| Itraconazole | 200 mg PO every 12 h | TDM required |