Ferdinandus de Looze1,2, Marc Russo3, Mark Bloch4, Barney Montgomery5, Adrian Shephard6, Robert DeVito7. 1. AusTrials Pty Ltd, Sherwood, QLD, Australia. 2. School of Medicine, University of Queensland, Brisbane, QLD, Australia. 3. Hunter Clinical Research, Broadmeadow, Newcastle, NSW, Australia. 4. Holdsworth House Medical Practice, Darlinghurst, NSW, Australia. 5. Optimal Clinical Trials, Auckland, New Zealand. 6. Reckitt Benckiser Healthcare International Ltd, Slough, Berkshire, UK. 7. Reckitt Benckiser, Parsippany, NJ 07054-0225, USA.
Abstract
AIM: Evaluate the efficacy of flurbiprofen 8.75 mg spray for sore throat relief. PATIENTS & METHODS: Randomized, double-blind study in adults with sore throat due to upper respiratory tract infection who tookflurbiprofen (n = 249) or placebo spray (n = 256). Pain relief was assessed using the Sore Throat Relief Rating Scale. RESULTS:Flurbiprofen spray provided significantly greater relief versus placebo from 20 min to 6 h (p < 0.0001; maximum difference: 75 min). Sore throat severity was reduced ≥-2.2 on the Sore Throat Scale from 75 min to 6 h, indicating meaningful relief. Significantly more patients taking flurbiprofen spray reported ≥30 min of 'at least moderate' relief versus placebo over 6 h (p < 0.0001). Most adverse events were mild. CONCLUSION:Flurbiprofen spray provides rapid, long-lasting and clinically meaningful relief from sore throat (ANZCTR: ACTRN12612000457842).
RCT Entities:
AIM: Evaluate the efficacy of flurbiprofen 8.75 mg spray for sore throat relief. PATIENTS & METHODS: Randomized, double-blind study in adults with sore throat due to upper respiratory tract infection who took flurbiprofen (n = 249) or placebo spray (n = 256). Pain relief was assessed using the Sore Throat Relief Rating Scale. RESULTS:Flurbiprofen spray provided significantly greater relief versus placebo from 20 min to 6 h (p < 0.0001; maximum difference: 75 min). Sore throat severity was reduced ≥-2.2 on the Sore Throat Scale from 75 min to 6 h, indicating meaningful relief. Significantly more patients taking flurbiprofen spray reported ≥30 min of 'at least moderate' relief versus placebo over 6 h (p < 0.0001). Most adverse events were mild. CONCLUSION:Flurbiprofen spray provides rapid, long-lasting and clinically meaningful relief from sore throat (ANZCTR: ACTRN12612000457842).
Authors: Sabiha Essack; John Bell; Douglas S Burgoyne; Martin Duerden; Adrian Shephard Journal: J Clin Pharm Ther Date: 2019-08-13 Impact factor: 2.512
Authors: Rob Turner; Sean Robert Wevrett; Suzanne Edmunds; Marc Brown; Anuradha Kulasekaran; Oluwajoba Adegoke; John Farrah Journal: Clin Pharmacol Date: 2021-01-19