Literature DB >> 29376491

Ganglioside GM3 and Its Role in Cancer.

Changping Zheng1, Marco Terreni2, Matthieu Sollogoub1, Yongmin Zhang1,3.   

Abstract

Ganglioside GM3 is strongly related with human tumors, such as lung, brain cancers and melanomas, and more and more evidences have revealed that GM3 possesses powerful effects on cancer development and progression. GM3 is over expressed on several types of cancers, and can be as a tumor-associated carbohydrate antigen, used for immunotherapy of cancers. GM3 can also inhibit tumor cells growth by anti-angiogenesis or motility and so on. Especially, GM3 has effects on the EGFR tyrosine kinase signaling, uPAR-related signaling and glycolipid-enriched microdomains, which are essential for cancer signaling conduction. It is obvious that GM3 will be a promising target for cancer treatment. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Entities:  

Keywords:  EGFR; GM3; GM3-enriched microdomains; anti-angiogenesis; antitumor; cell motility; immunotherapy; uPAR-related signaling.

Mesh：

Substances：

Year:  2019        PMID： 29376491     DOI： 10.2174/0929867325666180129100619

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN： 0929-8673            Impact factor:   4.530


  15 in total

1.  Synthesis of an Aminooxy Derivative of the GM3 Antigen and Its Application in Oxime Ligation.

Authors:  Kristopher A Kleski; Mengchao Shi; Matthew Lohman; Gabrielle T Hymel; Vinod K Gattoji; Peter R Andreana
Journal:  J Org Chem       Date:  2020-05-01       Impact factor: 4.354

Review 2.  Gangliosides play important roles in the nervous system by regulating ion concentrations.

Authors:  Yijia Xu; Jianfang Sun; Liying Yang; Shangfeng Zhao; Xin Liu; Yang Su; Jinghai Zhang; Mingyi Zhao
Journal:  Neurochem Res       Date:  2022-04-15       Impact factor: 3.996

3.  Chemoenzymatic Synthesis and Facile Purification of Gangliosides.

Authors:  Yuanyuan Bai; Hai Yu; Xi Chen
Journal:  Curr Protoc       Date:  2021-03

Review 4.  Plant-Derived Lectins as Potential Cancer Therapeutics and Diagnostic Tools.

Authors:  Milena Mazalovska; J Calvin Kouokam
Journal:  Biomed Res Int       Date:  2020-05-15       Impact factor: 3.411

Review 5.  Don't sugarcoat it: How glycocalyx composition influences cancer progression.

Authors:  Alexander Buffone; Valerie M Weaver
Journal:  J Cell Biol       Date:  2020-01-06       Impact factor: 10.539

Review 6.  Cholesterol and Sphingolipid Enriched Lipid Rafts as Therapeutic Targets in Cancer.

Authors:  Michela Codini; Mercedes Garcia-Gil; Elisabetta Albi
Journal:  Int J Mol Sci       Date:  2021-01-13       Impact factor: 5.923

7.  Liver sphingomyelin synthase 1 deficiency causes steatosis, steatohepatitis, fibrosis, and tumorigenesis: An effect of glucosylceramide accumulation.

Authors:  Zhiqiang Li; Yeun-Po Chiang; Mulin He; Tilla S Worgall; Hongwen Zhou; Xian-Cheng Jiang
Journal:  iScience       Date:  2021-11-15

8.  High-coverage targeted lipidomics revealed dramatic lipid compositional changes in asthenozoospermic spermatozoa and inverse correlation of ganglioside GM3 with sperm motility.

Authors:  Shuqiang Chen; Ming Wang; Li Li; Jun Wang; Xuhui Ma; Hengde Zhang; Yang Cai; Bin Kang; Jianlei Huang; Bo Li
Journal:  Reprod Biol Endocrinol       Date:  2021-07-07       Impact factor: 5.211

9.  Chemoenzymatic Total Synthesis of GM3 Gangliosides Containing Different Sialic Acid Forms and Various Fatty Acyl Chains.

Authors:  Hai Yu; Madhusudhan Reddy Gadi; Yuanyuan Bai; Libo Zhang; Lei Li; Jun Yin; Peng G Wang; Xi Chen
Journal:  J Org Chem       Date:  2021-06-21       Impact factor: 4.198

10.  Enhanced Anti-Atherosclerotic Efficacy of pH-Responsively Releasable Ganglioside GM3 Delivered by Reconstituted High-Density Lipoprotein.

Authors:  Tong Rong; Bo Wei; Meiying Ao; Haonan Zhao; Yuanfang Li; Yang Zhang; Ying Qin; Jinhua Zhou; Fenfen Zhou; Yong Chen
Journal:  Int J Mol Sci       Date:  2021-12-20       Impact factor: 5.923
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