Literature DB >> 2937512

Inactivation of atrial natriuretic factor in blood.

A T Veress, C K Chong, H Sonnenberg.   

Abstract

Tissue extracts of rat heart atria contain a family of peptides with natriuretic and vasorelaxant properties. It has been shown by others that inactivation of this atrial natriuretic factor may involve endogenous peptidases. The present experiments demonstrate that incubation in blood in vitro reduces the natriuretic activity of the factor. Specifically, inactivation was associated with a white cell/platelet fraction, indicating that these blood elements may play a physiological role in the metabolism of this new putative hormone.

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Year:  1985        PMID： 2937512     DOI： 10.1139/y85-267

Source DB:  PubMed          Journal:  Can J Physiol Pharmacol        ISSN： 0008-4212            Impact factor:   2.273


  4 in total

1.  Particulate guanylate cyclase and adenylate cyclase activities after activation with various agents in rabbit platelets. An ultracytochemical study.

Authors:  A Spreca; M G Rambotti; R Donato
Journal:  Histochem J       Date:  1991-03

2.  Clearance and early hydrolysis of atrial natriuretic factor in vivo. Structural analysis of cleavage sites and design of an analogue that inhibits hormone cleavage.

Authors:  C L Condra; E A Leidy; P Bunting; C D Colton; R F Nutt; M Rosenblatt; J W Jacobs
Journal:  J Clin Invest       Date:  1988-05       Impact factor: 14.808

3.  Clearance of atrial natriuretic factor by lung, liver, and kidney in human subjects and the dog.

Authors:  A S Hollister; R J Rodeheffer; F J White; J R Potts; T Imada; T Inagami
Journal:  J Clin Invest       Date:  1989-02       Impact factor: 14.808

4.  Degradation of atrial natriuretic factor in the rat.

Authors:  K K Murthy; G Thibault; R Garcia; J Gutkowska; J Genest; M Cantin
Journal:  Biochem J       Date:  1986-12-01       Impact factor: 3.857
  4 in total

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