Rolfdieter Krause1,2,3, Rainer Stange4,2, Heinz Jürgen Roth5, Heinrich Kaase6, Andreas Michalsen4,2, Michael F Holick7. 1. Research Group Medical Heliotherapy, University of Medicine Berlin, Berlin, Germany rolfdieter.krause@gmx.de. 2. Department of Internal and Complementary Medicine, Immanuel Hospital, Berlin, Germany. 3. KfH-Curatorium for Dialysis and Kidney Transplantation, Neu-Isenburg, Germany. 4. Research Group Medical Heliotherapy, University of Medicine Berlin, Berlin, Germany. 5. Limbach Laboratory, Department of Endocrinology, Heidelberg, Germany. 6. Institute of Lighting Technics, Technical University, Berlin, Germany. 7. Section Endocrinology, Nutrition and Diabetes, Department of Medicine and Vitamin D, Skin and Bone Research Laboratory, Boston University School of Medicine, Boston, MA, U.S.A.
Abstract
BACKGROUND/AIM: Exposure of the skin to sunshine is the major natural source of vitamin D. In order to imitate this natural production of vitamin D for patients with chronic kidney disease, hemodialysis patients were exposed three times a week to radiation of the front part of both legs to normalize the vitamin D status. PATIENTS AND METHODS: Partial body UVB irradiation was performed during the routine dialysis session. Twenty-two patients took part, with a mean age of 61.7 (range=35-81) years. RESULTS: Serum levels of 25(OH)D3 and 1,25(OH)2D3 increased into the mid normal range. Intact parathyroid hormone decreased by 25% and osteocalcin by 45%. 24-Hour blood-pressure monitoring demonstrated decreases in systolic and diastolic blood pressure. CONCLUSION: Partial body exposure to UVB radiation normalized not only the serum level of 25(OH)D3, but also that of 1,25(OH)2D3, which resulted in a significant decrease in parathyroid hormone, osteocalcin levels, and also in blood pressure. Sunshine imitating UVB exposure utilizes the capacity of the skin to convert extrarenally vitamin D3 to 25(OH)D3 and 1,25(OH)2D3. Copyright
BACKGROUND/AIM: Exposure of the skin to sunshine is the major natural source of vitamin D. In order to imitate this natural production of vitamin D for patients with chronic kidney disease, hemodialysis patients were exposed three times a week to radiation of the front part of both legs to normalize the vitamin D status. PATIENTS AND METHODS: Partial body UVB irradiation was performed during the routine dialysis session. Twenty-two patients took part, with a mean age of 61.7 (range=35-81) years. RESULTS: Serum levels of 25(OH)D3 and 1,25(OH)2D3 increased into the mid normal range. Intact parathyroid hormone decreased by 25% and osteocalcin by 45%. 24-Hour blood-pressure monitoring demonstrated decreases in systolic and diastolic blood pressure. CONCLUSION: Partial body exposure to UVB radiation normalized not only the serum level of 25(OH)D3, but also that of 1,25(OH)2D3, which resulted in a significant decrease in parathyroid hormone, osteocalcin levels, and also in blood pressure. Sunshine imitating UVB exposure utilizes the capacity of the skin to convert extrarenally vitamin D3 to 25(OH)D3 and 1,25(OH)2D3. Copyright
Authors: Linda W Moore; Wadi N Suki; Keri E Lunsford; Omaima M Sabek; Richard J Knight; A Osama Gaber Journal: BMJ Open Date: 2019-02-22 Impact factor: 2.692