Jun-Ichi Saitoh1, Katsuyuki Shirai2, Takanori Abe2, Nobuteru Kubo2, Takeshi Ebara3, Tatsuya Ohno2, Koichi Minato4, Ryusei Saito5, Masanobu Yamada6, Takashi Nakano2. 1. Gunma University Heavy Ion Medical Center, Gunma, Japan junsaito@gunma-u.ac.jp. 2. Gunma University Heavy Ion Medical Center, Gunma, Japan. 3. Department of Radiation Oncology, Gunma Prefectural Cancer Center, Ota, Japan. 4. Department of Respiratory Medicine, Gunma Prefectural Cancer Center, Ota, Japan. 5. Department of Respiratory Medicine, National Hospital Organization Shibukawa Medical Center, Shibukawa, Japan. 6. Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan.
Abstract
BACKGROUND/AIM: The aim of this study was to assess the feasibility and safety of hypofractionated carbon-ion radiotherapy (C-ion RT) in patients with stage III non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: Patients with untreated, histologically proven, unresectable stage III NSCLC and not candidates for chemotherapy were included in this study. C-ion RT was planned and administered with 4 Gy (relative biological effectiveness (RBE)) in daily fractions for a total dose of 64 Gy (RBE) without combined chemotherapy. Dose-limiting toxicity (DLT) was defined as suspension of C-ion RT treatment for 2 weeks due to ≥ grade 2 pneumonitis, or any other ≥ grade 3 adverse event, or as any ≥ grade 4 adverse event within 3 months from the start of treatment. RESULTS: Six patients were treated between June 2013 and December 2014. The planned full dose of C-ion RT (64 Gy (RBE)) was completed in all patients. No patient developed DLT, and no patient experienced toxicities of ≥grade 3 severity. The overall response rate was 100%, and local tumor control was achieved in all patients during the survival period. CONCLUSION: Hypofractionated C-ion RT of patients with stage III NSCLC was feasible and well tolerated. Although the number of patients in this study was small, the results support further investigations to confirm the long-term therapeutic efficacy of this treatment. Copyright
BACKGROUND/AIM: The aim of this study was to assess the feasibility and safety of hypofractionated carbon-ion radiotherapy (C-ion RT) in patients with stage III non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: Patients with untreated, histologically proven, unresectable stage III NSCLC and not candidates for chemotherapy were included in this study. C-ion RT was planned and administered with 4 Gy (relative biological effectiveness (RBE)) in daily fractions for a total dose of 64 Gy (RBE) without combined chemotherapy. Dose-limiting toxicity (DLT) was defined as suspension of C-ion RT treatment for 2 weeks due to ≥ grade 2 pneumonitis, or any other ≥ grade 3 adverse event, or as any ≥ grade 4 adverse event within 3 months from the start of treatment. RESULTS: Six patients were treated between June 2013 and December 2014. The planned full dose of C-ion RT (64 Gy (RBE)) was completed in all patients. No patient developed DLT, and no patient experienced toxicities of ≥grade 3 severity. The overall response rate was 100%, and local tumor control was achieved in all patients during the survival period. CONCLUSION: Hypofractionated C-ion RT of patients with stage III NSCLC was feasible and well tolerated. Although the number of patients in this study was small, the results support further investigations to confirm the long-term therapeutic efficacy of this treatment. Copyright
Authors: Timothy D Malouff; Anita Mahajan; Sunil Krishnan; Chris Beltran; Danushka S Seneviratne; Daniel Michael Trifiletti Journal: Front Oncol Date: 2020-02-04 Impact factor: 5.738