H Kuno1,2, K Sakamaki3,4, S Fujii5, K Sekiya3, K Otani6, R Hayashi7, T Yamanaka4, O Sakai2,8,9, M Kusumoto3. 1. From the Departments of Diagnostic Radiology (H.K., K.S., M.K.) hkuno@east.ncc.go.jp. 2. Departments of Radiology (H.K., O.S.). 3. From the Departments of Diagnostic Radiology (H.K., K.S., M.K.). 4. Department of Biostatistics (K.S., T.Y.), Yokohama City University, Yokohama, Kanagawa, Japan. 5. Division of Pathology (S.F.), Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan. 6. Advanced Therapies Innovation Department (K.O.), Siemens Healthcare K.K., Shinagawa-ku, Tokyo, Japan. 7. Head and Neck Surgery (R.H.), National Cancer Center Hospital East, Kashiwa, Chiba, Japan. 8. Otolaryngology-Head and Neck Surgery (O.S.). 9. Radiation Oncology (O.S.), Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts.
Abstract
BACKGROUND AND PURPOSE: Dual-energy CT can distinguish iodine-enhanced tumors from nonossified cartilage and has been investigated for evaluating cartilage invasion in patients with laryngeal and hypopharyngeal squamous cell carcinomas. In this study, we compared the diagnostic accuracy of MR imaging and of a combination of weighted-average and iodine overlay dual-energy CT images in detecting cartilage invasion by laryngeal and hypopharyngeal squamous cell carcinomas, in particular thyroid cartilage invasion. MATERIALS AND METHODS: Fifty-five consecutive patients who underwent 3T MR imaging and 128-slice dual-energy CT for preoperative initial staging of laryngeal or hypopharyngeal squamous cell carcinomas were included. Two blinded observers evaluated laryngeal cartilage invasion on MR imaging and dual-energy CT using a combination of weighted-average and iodine-overlay images. Pathologic findings of surgically resected specimens were used as the reference standard for evaluating sensitivity, specificity, and the areas under the receiver operating characteristic curve of both modalities for cartilage invasion by each type of cartilage and for all cartilages together. Sensitivity and specificity were compared using the McNemar test and generalized linear mixed models. RESULTS: Dual-energy CT showed higher specificity than MR imaging for diagnosing all cartilage together (84% for MR imaging versus 98% for dual-energy CT, P < .004) and for thyroid cartilage (64% versus 100%, P < .001), with a similar average area under the curve (0.94 versus 0.95, P = .70). The sensitivity did not differ significantly for all cartilages together (97% versus 81%, P = .16) and for thyroid cartilage (100% versus 89%, P = .50), though there was a trend toward increased sensitivity with MR imaging. CONCLUSIONS: Dual-energy CT showed higher specificity and acceptable sensitivity in diagnosing laryngeal cartilage invasion compared with MR imaging.
BACKGROUND AND PURPOSE: Dual-energy CT can distinguish iodine-enhanced tumors from nonossified cartilage and has been investigated for evaluating cartilage invasion in patients with laryngeal and hypopharyngeal squamous cell carcinomas. In this study, we compared the diagnostic accuracy of MR imaging and of a combination of weighted-average and iodine overlay dual-energy CT images in detecting cartilage invasion by laryngeal and hypopharyngeal squamous cell carcinomas, in particular thyroid cartilage invasion. MATERIALS AND METHODS: Fifty-five consecutive patients who underwent 3T MR imaging and 128-slice dual-energy CT for preoperative initial staging of laryngeal or hypopharyngeal squamous cell carcinomas were included. Two blinded observers evaluated laryngeal cartilage invasion on MR imaging and dual-energy CT using a combination of weighted-average and iodine-overlay images. Pathologic findings of surgically resected specimens were used as the reference standard for evaluating sensitivity, specificity, and the areas under the receiver operating characteristic curve of both modalities for cartilage invasion by each type of cartilage and for all cartilages together. Sensitivity and specificity were compared using the McNemar test and generalized linear mixed models. RESULTS: Dual-energy CT showed higher specificity than MR imaging for diagnosing all cartilage together (84% for MR imaging versus 98% for dual-energy CT, P < .004) and for thyroid cartilage (64% versus 100%, P < .001), with a similar average area under the curve (0.94 versus 0.95, P = .70). The sensitivity did not differ significantly for all cartilages together (97% versus 81%, P = .16) and for thyroid cartilage (100% versus 89%, P = .50), though there was a trend toward increased sensitivity with MR imaging. CONCLUSIONS: Dual-energy CT showed higher specificity and acceptable sensitivity in diagnosing laryngeal cartilage invasion compared with MR imaging.
Authors: Moritz H Albrecht; Jan-Erik Scholtz; Johannes Kraft; Ralf W Bauer; Moritz Kaup; Patricia Dewes; Andreas M Bucher; Iris Burck; Jens Wagenblast; Thomas Lehnert; J Matthias Kerl; Thomas J Vogl; Julian L Wichmann Journal: Eur Radiol Date: 2015-02-14 Impact factor: 5.315
Authors: David G Pfister; Scott A Laurie; Gregory S Weinstein; William M Mendenhall; David J Adelstein; K Kian Ang; Gary L Clayman; Susan G Fisher; Arlene A Forastiere; Louis B Harrison; Jean-Louis Lefebvre; Nancy Leupold; Marcy A List; Bernard O O'Malley; Snehal Patel; Marshall R Posner; Michael A Schwartz; Gregory T Wolf Journal: J Clin Oncol Date: 2006-07-10 Impact factor: 44.544
Authors: Liucija Weselik; Ewa Majchrzak; Matthew Ibbs; Adam Lewandowski; Andrzej Marszałek; Piotr Machczyński; Wojciech Golusiński Journal: Rep Pract Oncol Radiother Date: 2019-07-30