Literature DB >> 29371226

STINGing Antitumor Immunity into Action.

.   

Abstract

Efforts to stimulate STING signaling, thereby turning immunologically "cold" tumors "hot" and receptive to immunotherapy, are gaining ground in the industry. To date, directly targeting the STING receptor with synthetic ligands is the main approach to have entered clinical trials, but indirect small-molecule modulators of the pathway are also being pursued. ©2018 American Association for Cancer Research.

Entities:  

Mesh：

Substances：

Year:  2018        PMID： 29371226     DOI： 10.1158/2159-8290.CD-ND2018-002

Source DB:  PubMed          Journal:  Cancer Discov        ISSN： 2159-8274            Impact factor:   39.397


  4 in total

Review 1.  The Next Generation of Immunotherapy for Cancer: Small Molecules Could Make Big Waves.

Authors:  William G Kerr; John D Chisholm
Journal:  J Immunol       Date:  2019-01-01       Impact factor: 5.422

2.  Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer.

Authors:  Shunsuke Kitajima; Elena Ivanova; Sujuan Guo; Ryohei Yoshida; Marco Campisi; Shriram K Sundararaman; Shoichiro Tange; Yoichiro Mitsuishi; Tran C Thai; Sayuri Masuda; Brandon P Piel; Lynette M Sholl; Paul T Kirschmeier; Cloud P Paweletz; Hideo Watanabe; Mamiko Yajima; David A Barbie
Journal:  Cancer Discov       Date:  2018-10-08       Impact factor: 39.397

3.  Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer.

Authors:  Jessica L Ritter; Zehua Zhu; Tran C Thai; Navin R Mahadevan; Philipp Mertins; Erik H Knelson; Brandon P Piel; Saemi Han; Jacob D Jaffe; Steven A Carr; David A Barbie; Thanh U Barbie
Journal:  Cancer Res       Date:  2019-10-29       Impact factor: 12.701

4.  Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells.

Authors:  Simona Marzano; Giulia Miglietta; Rita Morigi; Jessica Marinello; Andrea Arleo; Monica Procacci; Alessandra Locatelli; Alberto Leoni; Bruno Pagano; Antonio Randazzo; Jussara Amato; Giovanni Capranico
Journal:  J Med Chem       Date:  2022-09-08       Impact factor: 8.039
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.