Dominika Janus1, Małgorzata Wójcik1, Katarzyna Tyrawa2, Magdalena Janeczko3, Mirosław Bik-Multanowski3, Kamil Fijorek4, Dorota Drozdz5, Kamila Kwiatek6, Jerzy B Starzyk1. 1. Department of Pediatric and Adolescent Endocrinology, Chair of Pediatrics, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland. 2. Department of Pediatric and Adolescent Endocrinology, Children's University Hospital in Krakow, Krakow, Poland. 3. Department of Genetics, Chair of Pediatrics, Institute of Pediatrics, Jagiellonian University Medical College and University Children Hospital, Kraków, Poland. 4. Department of Statistics, Cracow University of Economics, Krakow, Poland. 5. Department of Nephrology, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland. 6. Students Scientific Society, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.
Abstract
OBJECTIVE: Lifelong steroid therapy and exposure to adrenal androgen excess in 21-hydroxylase deficient (21-OHD) congenital adrenal hyperplasia (CAH) children and adolescents may modify circadian blood pressure profile and result in vascular complications. The objective of the study was to evaluate vascular abnormalities in 21-OHD children and adolescents in relation to their genotypes. DESIGN: A cross-sectional study conducted at a tertiary referral center. PATIENTS: Seventy patients with 21-OHD CAH (27 boys), aged from 3 to 17.9 years: 9 with nonclassic CAH, 61 with classic CAH: 10 with simple virilising (SV) and 51 with salt wasting CAH (13-Del/Del, 8-Del/I2G, 7-I2G/I2G and 23-other genotypes). MAIN OUTCOMES MEASURES: The assessment of systolic and diastolic BP (SBP, DBP) loads, night dip% and arterial ambulatory stiffness index (AASI) in 21-OHD CAH patients.
OBJECTIVE: Lifelong steroid therapy and exposure to adrenal androgen excess in 21-hydroxylase deficient (21-OHD) congenital adrenal hyperplasia (CAH) children and adolescents may modify circadian blood pressure profile and result in vascular complications. The objective of the study was to evaluate vascular abnormalities in 21-OHD children and adolescents in relation to their genotypes. DESIGN: A cross-sectional study conducted at a tertiary referral center. PATIENTS: Seventy patients with 21-OHD CAH (27 boys), aged from 3 to 17.9 years: 9 with nonclassic CAH, 61 with classic CAH: 10 with simple virilising (SV) and 51 with salt wasting CAH (13-Del/Del, 8-Del/I2G, 7-I2G/I2G and 23-other genotypes). MAIN OUTCOMES MEASURES: The assessment of systolic and diastolic BP (SBP, DBP) loads, night dip% and arterial ambulatory stiffness index (AASI) in 21-OHD CAHpatients.