Makoto Obara1, Osamu Togao2, Gabriele M Beck3, Shuhei Shibukawa4,5, Tomoyuki Okuaki5,6, Masami Yoneyama1, Masanobu Nakamura1, Hiroshi Honda2, Marc Van Cauteren6. 1. Philips Electronics Japan Ltd., Healthcare, Shinagawa, Tokyo, Japan. 2. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 3. Philips Healthcare, Best, The Netherlands. 4. Department of Radiology, Tokai University Hospital, Isehara, Kanagawa, Japan. 5. Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan. 6. Philips Healthcare, Asia Pacific, Shinagawa, Tokyo, Japan.
Abstract
PURPOSE: 4D dynamic MR angiography (4D-MRA) using pseudo-continuous arterial spin labeling (pCASL), combined with Keyhole and View-sharing (4D-PACK) for scan acceleration, is introduced. Its validity for arterial inflow dynamics visualization was investigated through comparison with 4D-pCASL and contrast inherent inflow enhanced multiphase angiography (CINEMA). METHODS: Six healthy volunteers were included in the study. The arterial transit time (ATT) in 4D-PACK was measured at multiple regions in middle cerebral artery (MCA), and Pearson's correlation coefficient with ATT in 4D-pCASL was calculated. The contrast-to-noise ratio (CNR) in 4D-PACK was measured in four MCA segments and compared with that in 4D-pCASL and CINEMA. Arterial visualization in 4D-PACK was assessed qualitatively in patients with moyamoya disease and arteriovenous malformation by comparing with CINEMA. RESULTS: 4D-PACK achieved a 36% scan time reduction compared with 4D-pCASL. The correlation coefficient for ATT measured by 4D-pCASL and 4D-PACK was greater than 0.96. The CNR was significantly higher using 4D-PACK compared with CINEMA in the M4 segment (P < 0.01). In patient examinations, the flow in the collateral artery or draining vein was better visualized in 4D-PACK compared with CINEMA. CONCLUSION: 4D-PACK accelerates 4D-pCASL, shows similar inflow dynamics as 4D-pCASL and shows better peripheral visualization compared with CINEMA. Magn Reson Med 80:719-725, 2018.
PURPOSE: 4D dynamic MR angiography (4D-MRA) using pseudo-continuous arterial spin labeling (pCASL), combined with Keyhole and View-sharing (4D-PACK) for scan acceleration, is introduced. Its validity for arterial inflow dynamics visualization was investigated through comparison with 4D-pCASL and contrast inherent inflow enhanced multiphase angiography (CINEMA). METHODS: Six healthy volunteers were included in the study. The arterial transit time (ATT) in 4D-PACK was measured at multiple regions in middle cerebral artery (MCA), and Pearson's correlation coefficient with ATT in 4D-pCASL was calculated. The contrast-to-noise ratio (CNR) in 4D-PACK was measured in four MCA segments and compared with that in 4D-pCASL and CINEMA. Arterial visualization in 4D-PACK was assessed qualitatively in patients with moyamoya disease and arteriovenous malformation by comparing with CINEMA. RESULTS: 4D-PACK achieved a 36% scan time reduction compared with 4D-pCASL. The correlation coefficient for ATT measured by 4D-pCASL and 4D-PACK was greater than 0.96. The CNR was significantly higher using 4D-PACK compared with CINEMA in the M4 segment (P < 0.01). In patient examinations, the flow in the collateral artery or draining vein was better visualized in 4D-PACK compared with CINEMA. CONCLUSION: 4D-PACK accelerates 4D-pCASL, shows similar inflow dynamics as 4D-pCASL and shows better peripheral visualization compared with CINEMA. Magn Reson Med 80:719-725, 2018.
Authors: O Togao; M Obara; K Kikuchi; M Helle; K Arimura; A Nishimura; T Wada; H Murazaki; M Van Cauteren; A Hiwatashi; K Ishigami Journal: AJNR Am J Neuroradiol Date: 2022-03-03 Impact factor: 3.825