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Literature DB >> 29367274

Biogenesis of zinc storage granules in Drosophila melanogaster.

Carlos Tejeda-Guzmán¹, Abraham Rosas-Arellano¹, Thomas Kroll², Samuel M Webb², Martha Barajas-Aceves³, Beatriz Osorio¹, Fanis Missirlis⁴.

Abstract

Membrane transporters and sequestration mechanisms concentrate metal ions differentially into discrete subcellular microenvironments for use in protein cofactors, signalling, storage or excretion. Here we identify zinc storage granules as the insect's major zinc reservoir in principal Malpighian tubule epithelial cells of Drosophila melanogaster The concerted action of Adaptor Protein-3, Rab32, HOPS and BLOC complexes as well as of the white-scarlet (ABCG2-like) and ZnT35C (ZnT2/ZnT3/ZnT8-like) transporters is required for zinc storage granule biogenesis. Due to lysosome-related organelle defects caused by mutations in the homologous human genes, patients with Hermansky-Pudlak syndrome may lack zinc granules in beta pancreatic cells, intestinal paneth cells and presynaptic vesicles of hippocampal mossy fibers.

Entities: Chemical Disease Gene Species

Keywords: AP-3 complex; Eye color mutants; ICP-OES; Malpighian tubules; Synchrotron; Zincosomes

Mesh：

Substances：
Drosophila Proteins
Zinc

Year: 2018 PMID： 29367274 PMCID： PMC5897703 DOI： 10.1242/jeb.168419

Source DB: PubMed Journal: J Exp Biol ISSN： 0022-0949 Impact factor: 3.312

179 in total

1. RNAi-mediated suppression of the mitochondrial iron chaperone, frataxin, in Drosophila.

Authors: Peter R Anderson; Kim Kirby; Arthur J Hilliker; John P Phillips
Journal: Hum Mol Genet Date: 2005-10-03 Impact factor: 6.150

2. THE INSULIN AND THE ZINC CONTENT OF NORMAL AND DIABETIC PANCREAS.

Authors: D A Scott; A M Fisher
Journal: J Clin Invest Date: 1938-11 Impact factor: 14.808

3. Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet.

Authors: C E Ooi; J E Moreira; E C Dell'Angelica; G Poy; D A Wassarman; J S Bonifacino
Journal: EMBO J Date: 1997-08-01 Impact factor: 11.598

4. Timing of Locomotor Recovery from Anoxia Modulated by the white Gene in Drosophila.

Authors: Chengfeng Xiao; R Meldrum Robertson
Journal: Genetics Date: 2016-03-30 Impact factor: 4.562

5. Inhibition of the PI3K-Akt signaling pathway disrupts ABCG2-rich extracellular vesicles and overcomes multidrug resistance in breast cancer cells.

Authors: Vicky Goler-Baron; Irina Sladkevich; Yehuda G Assaraf
Journal: Biochem Pharmacol Date: 2012-02-08 Impact factor: 5.858

6. Dm1-MMP, a matrix metalloproteinase from Drosophila with a potential role in extracellular matrix remodeling during neural development.

Authors: E Llano; A M Pendás; P Aza-Blanc; T B Kornberg; C López-Otín
Journal: J Biol Chem Date: 2000-11-17 Impact factor: 5.157

7. Transport defects as the physiological basis for eye color mutants of Drosophila melanogaster.

Authors: D T Sullivan; M C Sullivan
Journal: Biochem Genet Date: 1975-10 Impact factor: 1.890

Review 8. Hermansky-Pudlak syndrome: health care throughout life.

Authors: Samuel L Seward; William A Gahl
Journal: Pediatrics Date: 2013-06-10 Impact factor: 7.124

Review 9. Ironing out Ferroportin.

Authors: Hal Drakesmith; Elizabeta Nemeth; Tomas Ganz
Journal: Cell Metab Date: 2015-10-01 Impact factor: 27.287

Review 10. Zinc in Pancreatic Islet Biology, Insulin Sensitivity, and Diabetes.

Authors: Wolfgang Maret
Journal: Prev Nutr Food Sci Date: 2017-03-31

16 in total

Review 1. The Tiny Drosophila Melanogaster for the Biggest Answers in Huntington's Disease.

Authors: Abraham Rosas-Arellano; Argel Estrada-Mondragón; Ricardo Piña; Carola A Mantellero; Maite A Castro
Journal: Int J Mol Sci Date: 2018-08-14 Impact factor: 5.923

Review 2. The road to lysosome-related organelles: Insights from Hermansky-Pudlak syndrome and other rare diseases.

Authors: Shanna L Bowman; Jing Bi-Karchin; Linh Le; Michael S Marks
Journal: Traffic Date: 2019-06 Impact factor: 6.215

3. An ABCG Transporter Functions in Rab Localization and Lysosome-Related Organelle Biogenesis in Caenorhabditis elegans.

Authors: Laura Voss; Olivia K Foster; Logan Harper; Caitlin Morris; Sierra Lavoy; James N Brandt; Kimberly Peloza; Simran Handa; Amanda Maxfield; Marie Harp; Brian King; Victoria Eichten; Fiona M Rambo; Greg J Hermann
Journal: Genetics Date: 2019-12-17 Impact factor: 4.562

Biogenesis of zinc storage granules in Drosophila melanogaster.

1. RNAi-mediated suppression of the mitochondrial iron chaperone, frataxin, in Drosophila.

2. THE INSULIN AND THE ZINC CONTENT OF NORMAL AND DIABETIC PANCREAS.

3. Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet.

4. Timing of Locomotor Recovery from Anoxia Modulated by the white Gene in Drosophila.

5. Inhibition of the PI3K-Akt signaling pathway disrupts ABCG2-rich extracellular vesicles and overcomes multidrug resistance in breast cancer cells.

6. Dm1-MMP, a matrix metalloproteinase from Drosophila with a potential role in extracellular matrix remodeling during neural development.

7. Transport defects as the physiological basis for eye color mutants of Drosophila melanogaster.

Review 8. Hermansky-Pudlak syndrome: health care throughout life.

Review 9. Ironing out Ferroportin.

Review 10. Zinc in Pancreatic Islet Biology, Insulin Sensitivity, and Diabetes.

Review 1. The Tiny Drosophila Melanogaster for the Biggest Answers in Huntington's Disease.

Review 2. The road to lysosome-related organelles: Insights from Hermansky-Pudlak syndrome and other rare diseases.

3. An ABCG Transporter Functions in Rab Localization and Lysosome-Related Organelle Biogenesis in Caenorhabditis elegans.

4. Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster.

Review 5. Metal ions in insect reproduction: a crosstalk between reproductive physiology and immunity.

6. Determination of Metal Content in Drosophila melanogaster During Metal Exposure.

Review 7. Zinc homeostasis in the secretory pathway in yeast.

8. Iron Sulfur and Molybdenum Cofactor Enzymes Regulate the Drosophila Life Cycle by Controlling Cell Metabolism.

Review 9. Physiology, Development, and Disease Modeling in the Drosophila Excretory System.

Review 10. Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster.