| Literature DB >> 29366837 |
Zhe Chen1, Lu He1, Lanfang Li2, Linxi Chen3.
Abstract
The P2X7 purinergic receptor, a calcium permeable cationic channel, is activated by extracellular ATP. Most studies show that P2X7 receptor plays an important role in the nervous system diseases, immune response, osteoporosis and cancer. Mounting evidence indicates that P2X7 receptor is also associated with cardiovascular disease. For example, the P2X7 receptor activated by ATP can attenuate myocardial ischemia-reperfusion injury. By contrast, inhibition of P2X7 receptor decreases arrhythmia after myocardial infarction, prolongs cardiac survival after a long term heart transplant, alleviates the dilated cardiomyopathy and the autoimmune myocarditis process. The P2X7 receptor also mitigates vascular diseases including atherosclerosis, hypertension, thrombosis and diabetic retinopathy. This review focuses on the latest research on the role and therapeutic potential of P2X7 receptor in cardiovascular diseases.Entities:
Keywords: Atherosclerosis; Autoimmune myocarditis; Diabetic retinopathy; Dilated cardiomyopathy; Myocardial ischemia-reperfusion injury; The P2X7 receptor
Mesh：
Substances：
Year: 2018 PMID： 29366837 DOI： 10.1016/j.cca.2018.01.032
Source DB: PubMed Journal: Clin Chim Acta ISSN： 0009-8981 Impact factor: 3.786