Literature DB >> 2936531

Serotonin as a mediator of cyclic flow variations in stenosed canine coronary arteries.

J H Ashton, C R Benedict, C Fitzgerald, S Raheja, A Taylor, W B Campbell, L M Buja, J T Willerson.   

Abstract

The data obtained in this study demonstrate that the concentration of serotonin is markedly elevated (18- to 27-fold) at the site of a coronary arterial stenosis in open-chest, anesthetized dogs with cyclic flow variations. Cyclic flow variations in this experimental preparation were abolished by ketanserin, a 5-hydroxytryptamine antagonist, but serotonin concentration at the site of the coronary stenosis remained elevated. The intra-atrial administration of serotonin (0.16 to 1 mg/min) restored cyclic flow variations after they had been abolished by ketanserin. Taken together, these data suggest that serotonin may be one of the important mediators of cyclic flow variations in this experimental preparation.

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Year:  1986        PMID： 2936531     DOI： 10.1161/01.cir.73.3.572

Source DB:  PubMed          Journal:  Circulation        ISSN： 0009-7322            Impact factor:   29.690


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