Farhad Hajizadeh1, Bahman Derakhshan2, Ali Peimani3, Zahra Abbasi4. 1. Department of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. 2. Department of Oral and Maxillofacial Surgery, International Campus School of Dentistry, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. 3. Department of Oral and Maxillofacial Surgery, Rafsanjan University of Medical Sciences, Rafsanjan, Islamic Republic of Iran. 4. Department of Otolaryngology-Head and Neck Surgery Hamedan University of Medical Sciences, Hamedan, Islamic Republic of Iran, Phone: +989125176083, e-mail: abbasizahra@yahoo.com.
Abstract
AIM: In medicine, honey is known for its various biological or pharmacological effects, from wound dressing to anticancero-genic and from anti-inflammatory to antibacterial activities. The aim of the current study was to evaluate the effect of honey on healing of mandibular bone defects in a rat model. MATERIALS AND METHODS: This animal study was performed on 24 wild-type Wistar rats. Following shaving, disinfection, and extraoral incision, a 2 × 2 mm defect was created at mandibular angle. In the experimental group, the defect was filled with sterile honey, while it was left unfilled in the control group. The rats were sacrificed after 2 and 4 weeks and defects were assessed histologically. The results were compared using Mann-Whitney U-test (α = 0.05). RESULTS: After 2 weeks, five samples of the experimental group were in mineralization phase, while all samples of the control group were in the vascularization phase (p = 0.015). After 4 weeks, the defects were filled in four samples of the experimental group, while all samples of the control group were in the mineralization stage (p = 0.002). Histomorphometric assessment revealed that the mean new bone formation in the experimental group was significantly more than the control group, both after 2 and 4 weeks (p = 0.041). CONCLUSION: The results showed that honey could accentuate bone healing of mandibular small defects in rats. CLINICAL SIGNIFICANCE: Honey might have potential in repair of human alveolar bone defects.
AIM: In medicine, honey is known for its various biological or pharmacological effects, from wound dressing to anticancero-genic and from anti-inflammatory to antibacterial activities. The aim of the current study was to evaluate the effect of honey on healing of mandibular bone defects in a rat model. MATERIALS AND METHODS: This animal study was performed on 24 wild-type Wistar rats. Following shaving, disinfection, and extraoral incision, a 2 × 2 mm defect was created at mandibular angle. In the experimental group, the defect was filled with sterile honey, while it was left unfilled in the control group. The rats were sacrificed after 2 and 4 weeks and defects were assessed histologically. The results were compared using Mann-Whitney U-test (α = 0.05). RESULTS: After 2 weeks, five samples of the experimental group were in mineralization phase, while all samples of the control group were in the vascularization phase (p = 0.015). After 4 weeks, the defects were filled in four samples of the experimental group, while all samples of the control group were in the mineralization stage (p = 0.002). Histomorphometric assessment revealed that the mean new bone formation in the experimental group was significantly more than the control group, both after 2 and 4 weeks (p = 0.041). CONCLUSION: The results showed that honey could accentuate bone healing of mandibular small defects in rats. CLINICAL SIGNIFICANCE: Honey might have potential in repair of humanalveolar bone defects.
Authors: Mohd Amir Kamaruzzaman; Kok-Yong Chin; Elvy Suhana Mohd Ramli Journal: Evid Based Complement Alternat Med Date: 2019-09-19 Impact factor: 2.629