Glycogen Phosphorylase: A Novel Biomarker in Doxorubicin-Induced Cardiac Injury.

Extracellular vesicles containing glycogen phosphorylase, brain/heart (PYGB) have been demonstrated as a sensitive biomarker for normal cardiac injuries for patients after chemotherapy. Oxidative stress was suggested to be the mechanism behind the chemotherapy-induced tissue damage and augmented with mitochondrial antioxidant could be an effective means of early intervention. Clin Cancer Res; 24(7); 1516-7. ©2018 AACRSee related article by Yarana et al., p. 1644. ©2018 American Association for Cancer Research.