Literature DB >> 29358037

Antidepressant-Induced Activation in Children and Adolescents: Risk, Recognition and Management.

Marissa J Luft1, Martine Lamy2, Melissa P DelBello3, Robert K McNamara1, Jeffrey R Strawn4.   

Abstract

The tolerability of antidepressants is poorly characterized in children and adolescents with depressive and anxiety disorders. Among adverse events that affect the tolerability of antidepressants in youth is activation, a cluster of symptoms that represent a hyperarousal event characterized by impulsivity, restlessness, and/or insomnia. This cluster of symptoms was first identified as a side effect of selective serotonin and selective serotonin norepinephrine inhibitors (SSRIs and SSNRIs) in the early 1990s; however, activation remains poorly characterized in terms of prevalence, risk factors, and pathophysiology. This article describes the pathophysiology of antidepressant-related activation, predictors of activation and its clinical management in youth with depressive and anxiety disorders who are treated with antidepressant medications.
Copyright © 2018 Mosby, Inc. All rights reserved.

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Year:  2018        PMID： 29358037      PMCID： PMC5828909          DOI： 10.1016/j.cppeds.2017.12.001

Source DB:  PubMed          Journal:  Curr Probl Pediatr Adolesc Health Care        ISSN： 1538-3199


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