Alice Lopes1,2, Isabel Fonseca1,3, Alexandra Sousa1, Carla Rodrigues1, Margarida Branco1, Teresa Coelho1,4, Jorge Sequeiros2,5, Paula Freitas1,2. 1. a Serviço de Psiquiatria e Saúde Mental , Centro Hospitalar do Porto , Porto , Portugal. 2. b ICBAS - Instituto de Ciências Biomédicas Abel Salazar , Universidade do Porto , Porto , Portugal. 3. c EPIUnit , Instituto de Saúde Pública da Universidade do Porto (ISPUP) , Porto , Portugal. 4. d Serviço de Neurofisiologia , Centro Hospitalar do Porto , Porto , Portugal. 5. e IBMC - Institute for Molecular and Cell Biology and i3S , Instituto de Investigação e Inovação em Saúde, Universidade do Porto , Porto , Portugal.
Abstract
BACKGROUND: Chronic physical illness has been associated with emotional distress. Chronic diseases may change usual family patterns with economic, social and family losses. Hereditary ATTR V30M amyloidosis is a rare, fatal inherited systemic amyloidosis, with chronic evolution and beginning in adulthood. AIMS AND METHODS: To evaluate psychopathological dimensions and how they correlated with disease-related life events, 209 symptomatic and asymptomatic carriers, participated in the study. Sociodemographic and Family and Personal History Disease questionnaires and brief symptom inventory (BSI) were applied. RESULTS: BSI indices, global severity index (GSI), positive symptom index (PSI) and positive symptom total (PST) scored higher than general population. Independent predictors for GSI >0.83 were female sex (OR = 3.46, p = .005) and being symptomatic carriers (OR = 3.03, p = .039). Independent predictors of a PST >26.99 were female sex (OR = 3.74, p = .012) symptomatic carrier (OR = 5.32, p = .025), age between 15 and 24 years at affected parent's death (OR = 5.26, p = .04). Independent predictors of a PSI >1.56 were being asymptomatic carrier (OR = 6.3, p = .036); to have children (OR = 3.19, p = .043) and have ≤14 years at parent's disease onset (OR = 6.39, p = .05). CONCLUSIONS: Results point to an important vulnerability of this population for psychological distress and psychiatric disease. Early life events related to disease, being sick and sex are associated with psychopathological distress.
BACKGROUND: Chronic physical illness has been associated with emotional distress. Chronic diseases may change usual family patterns with economic, social and family losses. Hereditary ATTRV30Mamyloidosis is a rare, fatal inherited systemic amyloidosis, with chronic evolution and beginning in adulthood. AIMS AND METHODS: To evaluate psychopathological dimensions and how they correlated with disease-related life events, 209 symptomatic and asymptomatic carriers, participated in the study. Sociodemographic and Family and Personal History Disease questionnaires and brief symptom inventory (BSI) were applied. RESULTS: BSI indices, global severity index (GSI), positive symptom index (PSI) and positive symptom total (PST) scored higher than general population. Independent predictors for GSI >0.83 were female sex (OR = 3.46, p = .005) and being symptomatic carriers (OR = 3.03, p = .039). Independent predictors of a PST >26.99 were female sex (OR = 3.74, p = .012) symptomatic carrier (OR = 5.32, p = .025), age between 15 and 24 years at affected parent's death (OR = 5.26, p = .04). Independent predictors of a PSI >1.56 were being asymptomatic carrier (OR = 6.3, p = .036); to have children (OR = 3.19, p = .043) and have ≤14 years at parent's disease onset (OR = 6.39, p = .05). CONCLUSIONS: Results point to an important vulnerability of this population for psychological distress and psychiatric disease. Early life events related to disease, being sick and sex are associated with psychopathological distress.
Authors: Maria do Carmo Vilas-Boas; Ana Patrícia Rocha; Márcio Neves Cardoso; José Maria Fernandes; Teresa Coelho; João Paulo Silva Cunha Journal: Front Neurol Date: 2020-11-23 Impact factor: 4.086