Literature DB >> 29357009

The matricellular protein CCN1 in tissue injury repair.

Ki-Hyun Kim1, Jong Hoon Won1, Naiyuan Cheng1, Lester F Lau2.   

Abstract

The expression of Ccn1 (Cyr61) is essential for cardiovascular development during embryogenesis, whereas in adulthood it is associated with inflammation, wound healing, injury repair, and related pathologies including fibrosis and cancer. Recent studies have found that CCN1 plays a critical role in promoting wound healing and tissue repair. Mechanistically, CCN1 functions through direct interaction with specific integrin receptors expressed in various cell types in the wound tissue microenvironment to coordinate diverse cellular functions for repair. Here we briefly summarize the current knowledge on the functions of CCN1 in tissue injury repair and discuss pertinent unanswered questions.

Entities:  

Keywords:  inflammation; injury repair; integrin; tissue regeneration; wound healing

Year:  2018        PMID： 29357009      PMCID： PMC5842204          DOI： 10.1007/s12079-018-0450-x

Source DB:  PubMed          Journal:  J Cell Commun Signal        ISSN： 1873-9601            Impact factor:   5.782


  60 in total

1.  CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth.

Authors:  A M Babic; M L Kireeva; T V Kolesnikova; L F Lau
Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-26       Impact factor: 11.205

Review 2.  Cell surface receptors for CCN proteins.

Authors:  Lester F Lau
Journal:  J Cell Commun Signal       Date:  2016-04-20       Impact factor: 5.782

Review 3.  Macrophages in Tissue Repair, Regeneration, and Fibrosis.

Authors:  Thomas A Wynn; Kevin M Vannella
Journal:  Immunity       Date:  2016-03-15       Impact factor: 31.745

4.  Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.

Authors:  L F Lau; D Nathans
Journal:  Proc Natl Acad Sci U S A       Date:  1987-03       Impact factor: 11.205

5.  O-Fucosylation of CCN1 is required for its secretion.

Authors:  Yuki Niwa; Takehiro Suzuki; Naoshi Dohmae; Siro Simizu
Journal:  FEBS Lett       Date:  2015-09-28       Impact factor: 4.124

6.  The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling.

Authors:  Erawan Borkham-Kamphorst; Christian Schaffrath; Eddy Van de Leur; Ute Haas; Lidia Tihaa; Steffen K Meurer; Yulia A Nevzorova; Christian Liedtke; Ralf Weiskirchen
Journal:  Biochim Biophys Acta       Date:  2014-01-31

7.  Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts.

Authors:  Ki-Hyun Kim; Chih-Chiun Chen; Ricardo I Monzon; Lester F Lau
Journal:  Mol Cell Biol       Date:  2013-03-18       Impact factor: 4.272

Review 8.  Functions and mechanisms of action of CCN matricellular proteins.

Authors:  Chih-Chiun Chen; Lester F Lau
Journal:  Int J Biochem Cell Biol       Date:  2008-08-15       Impact factor: 5.085

9.  TNFα-induced apoptosis enabled by CCN1/CYR61: pathways of reactive oxygen species generation and cytochrome c release.

Authors:  Vladislava Juric; Chih-Chiun Chen; Lester F Lau
Journal:  PLoS One       Date:  2012-02-17       Impact factor: 3.240

Review 10.  The myofibroblast in wound healing and fibrosis: answered and unanswered questions.

Authors:  Marie-Luce Bochaton-Piallat; Giulio Gabbiani; Boris Hinz
Journal:  F1000Res       Date:  2016-04-26
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  24 in total

1.  Differential intolerance to loss of function and missense mutations in genes that encode human matricellular proteins.

Authors:  Sukhbir Kaur; David D Roberts
Journal:  J Cell Commun Signal       Date:  2021-01-07       Impact factor: 5.782

2.  [Angiotensin Ⅱ induces apoptosis of HEK293T cells by up-regulating Cyr61 expression].

Authors:  Junjie Wang; Yan Jiang; Senouthai Soulixay; Dongdong Fu; Yanwu You
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2019-07-30

3.  Depletion of CCN1/CYR61 reduces triple-negative/basal-like breast cancer aggressiveness.

Authors:  Ingrid Espinoza; Chandra Kurapaty; Cheol-Hong Park; Travis Vander Steen; Celina G Kleer; Elizabeth Wiley; Alfred Rademaker; Elisabet Cuyàs; Sara Verdura; Maria Buxó; Carol Reynolds; Javier A Menendez; Ruth Lupu
Journal:  Am J Cancer Res       Date:  2022-02-15       Impact factor: 6.166

Review 4.  The role of CCNs in controlling cellular communication in the tumor microenvironment.

Authors:  Lauren B Birkeness; Snigdha Banerjee; Mohiuddin Quadir; Sushanta K Banerjee
Journal:  J Cell Commun Signal       Date:  2022-06-08       Impact factor: 5.908

5.  The senescence-associated matricellular protein CCN1 in plasma of human subjects with idiopathic pulmonary fibrosis.

Authors:  Tejaswini Kulkarni; Ashish R Kurundkar; Young-Il Kim; Joao de Andrade; Tracy Luckhardt; Victor J Thannickal
Journal:  Respir Med       Date:  2019-11-19       Impact factor: 4.582

Review 6.  The Influence of the Extracellular Matrix in Inflammation: Findings from the SPARC-Null Mouse.

Authors:  Hannah J Riley; Amy D Bradshaw
Journal:  Anat Rec (Hoboken)       Date:  2019-04-24       Impact factor: 2.227

7.  Cellular senescence is a promising target for chronic wounds: a comprehensive review.

Authors:  Ziwen Wang; Chunmeng Shi
Journal:  Burns Trauma       Date:  2020-06-23

Review 8.  Emerging Roles of Matricellular Proteins in Systemic Sclerosis.

Authors:  Daniel Feng; Casimiro Gerarduzzi
Journal:  Int J Mol Sci       Date:  2020-07-06       Impact factor: 5.923

9.  Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss.

Authors:  Supawich Morkmued; François Clauss; Brigitte Schuhbaur; Valérie Fraulob; Eric Mathieu; Joseph Hemmerlé; Hans Clevers; Bon-Kyoung Koo; Pascal Dollé; Agnès Bloch-Zupan; Karen Niederreither
Journal:  Sci Rep       Date:  2020-09-09       Impact factor: 4.379

10.  Diabetes and baseline glucose are associated with inflammation, left ventricular function and short- and long-term outcome in acute coronary syndromes: role of the novel biomarker Cyr 61.

Authors:  Patric Winzap; Allan Davies; Roland Klingenberg; Slayman Obeid; Marco Roffi; François Mach; Lorenz Räber; Stephan Windecker; Christian Templin; Fabian Nietlispach; David Nanchen; Baris Gencer; Olivier Muller; Christian M Matter; Arnold von Eckardstein; Thomas F Lüscher
Journal:  Cardiovasc Diabetol       Date:  2019-10-31       Impact factor: 9.951
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