Literature DB >> 2935686

Changes in the 32P incorporation in rat mammary tumor after chronic administration of LH-RH analogs.

G Cehovic, T W Redding, A V Schally.   

Abstract

We studied endogenous phosphorylation in rat transplantable MT/W9A hormone-dependent mammary tumors of untreated rats and of animals treated with LH-RH analogs, the agonist D-Trp-6-LH-RH and the antagonist N-Ac-D-p-Cl-Phe1,2,D-Trp3,D-Arg6,D-Ala10-LH-RH. Incorporation of 32P from 32P-ATP was reduced significantly in tumors of rats treated with agonistic and antagonistic analogs of LH-RH or ovariectomized. The inhibition of protein phosphorylation may be related to tumor regression.

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Year:  1985        PMID： 2935686     DOI： 10.1007/bf02934909

Source DB:  PubMed          Journal:  Med Oncol Tumor Pharmacother        ISSN： 0736-0118


  23 in total

1.  Mammary tumors of the rat: a review.

Authors:  R L NOBLE; J H CUTTS
Journal:  Cancer Res       Date:  1959-12       Impact factor: 12.701

2.  Cyclic adenosine 3, 5'-monophosphate phosphodiesterase activity in normal & neoplastic murine mammary gland.

Authors:  N A Sheth; S S Tikekar; A R Sheth
Journal:  Indian J Exp Biol       Date:  1980-06       Impact factor: 0.818

3.  Interaction of adenosine 3',5'-monophosphate derivatives with the gonadotropin-releasing hormone receptor on pituitary and ovary.

Authors:  M A Smith; M H Perrin; W W Vale
Journal:  Endocrinology       Date:  1982-12       Impact factor: 4.736

4.  Stimulation of adenosine 3':5'-cyclic monophosphate accumulation in anterior pituitary gland in vitro by synthetic luteinizing hormone-releasing hormone.

Authors:  P Borgeat; G Chavancy; A Dupont; F Labrie; A Arimura; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1972-09       Impact factor: 11.205

5.  Tumor growth inhibition in patients with prostatic carcinoma treated with luteinizing hormone-releasing hormone agonists.

Authors:  G Tolis; D Ackman; A Stellos; A Mehta; F Labrie; A T Fazekas; A M Comaru-Schally; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

6.  Endogenous phosphorylation in Dunning prostate tumors of rats treated with LH-RH analogues.

Authors:  G Cehovic; T W Redding; M T Hierowski; A V Schally
Journal:  Prostate       Date:  1984       Impact factor: 4.104

7.  Inhibition of growth of a prolactin-secreting pituitary tumor in rats by analogs of luteinizing hormone-releasing hormone and somatostatin.

Authors:  M G de Quijada; T W Redding; D H Coy; I Torres-Aleman; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205

8.  Inhibition of growth of the transplantable rat chondrosarcoma by analogs of hypothalamic hormones.

Authors:  T W Redding; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

9.  Inhibition of prostate tumors by agonistic and antagonistic analogs of LH-RH.

Authors:  A V Schally; T W Redding; A M Comaru-Schally
Journal:  Prostate       Date:  1983       Impact factor: 4.104

10.  Inhibition of prostate tumor growth in two rat models by chronic administration of D-Trp6 analogue of luteinizing hormone-releasing hormone.

Authors:  T W Redding; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205
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