Sara E Parli1,2, Grishma Trivedi3, Alison Woodworth4, Phillip K Chang3. 1. 1 Department of Pharmacy Services, University of Kentucky HealthCare , Lexington, Kentucky. 2. 2 Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy , Lexington, Kentucky. 3. 4 Department of General Surgery, University of Kentucky College of Medicine , Lexington, Kentucky. 4. 3 Department of Pathology and Laboratory Medicine, University of Kentucky College of Medicine , Lexington, Kentucky.
Abstract
BACKGROUND: Procalcitonin (PCT) is a serum biomarker currently suggested by the Surviving Sepsis Campaign to aid in determination of the appropriate duration of therapy in sepsis patients. We review the use of procalcitonin in patients after trauma or acute care surgery. METHOD: A MEDLINE search via PubMed was performed using the combination of "procalcitonin" and "humans" and "injuries, trauma," "wounds and injuries," or "wounds." Studies of burn patients, children, other biomarkers, and non-acute care surgery were excluded. RESULTS: Procalcitonin may be useful in identifying infection in trauma and post-operative acute care surgery. However, heterogenity exists among patients, and surgery and trauma alone elevate PCT even in the absence of infection. CONCLUSIONS: Although trends in PCT concentrations may offer insight, no standard approach can be recommended currently.
BACKGROUND: Procalcitonin (PCT) is a serum biomarker currently suggested by the Surviving Sepsis Campaign to aid in determination of the appropriate duration of therapy in sepsispatients. We review the use of procalcitonin in patients after trauma or acute care surgery. METHOD: A MEDLINE search via PubMed was performed using the combination of "procalcitonin" and "humans" and "injuries, trauma," "wounds and injuries," or "wounds." Studies of burn patients, children, other biomarkers, and non-acute care surgery were excluded. RESULTS: Procalcitonin may be useful in identifying infection in trauma and post-operative acute care surgery. However, heterogenity exists among patients, and surgery and trauma alone elevate PCT even in the absence of infection. CONCLUSIONS: Although trends in PCT concentrations may offer insight, no standard approach can be recommended currently.
Entities:
Keywords:
general surgery; infection; post-operative complications; procalcitonin; wounds and injuries
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