Literature DB >> 29356007

The research evidence for schizophrenia as a neurodevelopmental disorder.

Bjorn Rishovd Rund1,2.   

Abstract

Schizophrenia is a neurodevelopmental disorder that starts very early. In this review we describe the empirical evidence for the neurodevelopmental model. First, by outlining the roots of psychological research that laid the foundation of the model. Thereafter, describing cognitive dysfunction observed in schizophrenia, and the course of cognitive functioning in the illness. Then, research findings that speak for and studies that speak against the view that schizophrenia is a degenerative process is discussed. We find that there is ample evidence that cognitive disturbance is a core element in schizophrenia. However, we have limited understanding of what initiates the abnormal development. This the paper ends with pointing out some of the factors that may trigger the deviant neurocognitive development in schizophrenia.
© 2018 Scandinavian Psychological Associations and John Wiley & Sons Ltd.

Entities:  

Keywords:  Schizophrenia; degeneration; neurocognition; neurodevelopmental

Mesh:

Year:  2018        PMID: 29356007     DOI: 10.1111/sjop.12414

Source DB:  PubMed          Journal:  Scand J Psychol        ISSN: 0036-5564


  14 in total

1.  Known and Unexplored Post-Translational Modification Pathways in Schizophrenia.

Authors:  Bradley J Smith; Victor C Carregari
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 3.650

2.  Domain-specific cognitive course in schizophrenia: Group- and individual-level changes over 10 years.

Authors:  Camilla Bärthel Flaaten; Ingrid Melle; Thomas Bjella; Magnus Johan Engen; Gina Åsbø; Kristin Fjelnseth Wold; Line Widing; Erlend Gardsjord; Linn-Sofie Sæther; Merete Glenne Øie; Siv Hege Lyngstad; Beathe Haatveit; Carmen Simonsen; Torill Ueland
Journal:  Schizophr Res Cogn       Date:  2022-06-22

3.  CACNA1C (rs1006737) may be a susceptibility gene for schizophrenia: An updated meta-analysis.

Authors:  Dongjian Zhu; Jingwen Yin; Chunmei Liang; Xudong Luo; Dong Lv; Zhun Dai; Susu Xiong; Jiawu Fu; You Li; Juda Lin; Zhixiong Lin; Yajun Wang; Guoda Ma
Journal:  Brain Behav       Date:  2019-04-29       Impact factor: 2.708

4.  Intracellular compartment-specific proteasome dysfunction in postmortem cortex in schizophrenia subjects.

Authors:  Madeline R Scott; James H Meador-Woodruff
Journal:  Mol Psychiatry       Date:  2019-01-25       Impact factor: 15.992

5.  Cognitive impairment in schizophrenia: relationships with cortical thickness in fronto-temporal regions, and dissociability from symptom severity.

Authors:  Erkan Alkan; Geoff Davies; Simon L Evans
Journal:  NPJ Schizophr       Date:  2021-03-18

6.  Role of Polyinosinic:Polycytidylic Acid-Induced Maternal Immune Activation and Subsequent Immune Challenge in the Behaviour and Microglial Cell Trajectory in Adult Offspring: A Study of the Neurodevelopmental Model of Schizophrenia.

Authors:  Katarzyna Chamera; Ewa Trojan; Katarzyna Kotarska; Magdalena Szuster-Głuszczak; Natalia Bryniarska; Kinga Tylek; Agnieszka Basta-Kaim
Journal:  Int J Mol Sci       Date:  2021-02-04       Impact factor: 5.923

7.  Ectodermal disturbance in development shared by anorexia and schizophrenia may reflect neurodevelopmental abnormalities.

Authors:  Barbara Remberk; Piotr Niwiński; Ewa Brzóska-Konkol; Anna Borowska; Anna Papasz-Siemieniuk; Joanna Brągoszewska; Anna Katarzyna Bażyńska; Łukasz Szostakiewicz; Anna Herman
Journal:  Brain Behav       Date:  2021-09-12       Impact factor: 2.708

8.  Never See an Adult Again.

Authors:  Himanshu Agrawal
Journal:  Acad Psychiatry       Date:  2021-06-08

9.  Premorbid adjustment amongst outpatients with schizophrenia in a Nigerian psychiatric facility.

Authors:  Omokehinde O Fakorede; Adegboyega Ogunwale; Akinwande O Akinhanmi
Journal:  S Afr J Psychiatr       Date:  2021-05-28       Impact factor: 1.550

10.  Transcriptome analysis of fibroblasts from schizophrenia patients reveals differential expression of schizophrenia-related genes.

Authors:  Mitra Etemadikhah; Adnan Niazi; Lennart Wetterberg; Lars Feuk
Journal:  Sci Rep       Date:  2020-01-20       Impact factor: 4.379

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