Adam T Hill1, Alan F Barker2, Donald C Bolser3, Paul Davenport4, Belinda Ireland5, Anne B Chang6, Stuart B Mazzone7, Lorcan McGarvey8. 1. Royal Infirmary and University of Edinburgh, Edinburgh, Scotland. Electronic address: adam.hill318@nhs.net. 2. Oregon Health & Science University, Portland, OR. 3. College of Veterinary Medicine, University of Florida, Gainesville, FL. 4. Department of Physiological Sciences, University of Florida, Gainesville, FL. 5. The Evidence Doc, Pacific, MO. 6. Menzies School of Health Research, Darwin, NT, Australia; Department of Respiratory and Sleep Medicine, Lady Cilento Children's Hospital, Queensland University of Technology, Brisbane, QLD, Australia. 7. University of Melbourne, VIC, Australia. 8. Queens University Belfast, Belfast, United Kingdom.
Abstract
BACKGROUND: In bronchiectasis due to cystic fibrosis (CF) and other causes, airway clearance is one of the mainstays of management. We conducted a systematic review on airway clearance by using non-pharmacological methods as recommended by international guidelines to develop recommendations or suggestions to update the 2006 CHEST guideline on cough. METHODS: The systematic search for evidence examined the question, "Is there evidence of clinically important treatment effects for non-pharmacological therapies in cough treatment for patients with bronchiectasis?" Populations selected were all patients with bronchiectasis due to CF or non-CF bronchiectasis. The interventions explored were the non-pharmacological airway clearance therapies. The comparison populations included those receiving standard therapy and/or placebo. Clinically important outcomes that were explored were exacerbation rates, quality of life, hospitalizations, and mortality. RESULTS: In both CF and non-CF bronchiectasis, there were systematic reviews and overviews of systematic reviews identified. Despite these findings, there were no large randomized controlled trials that explored the impact of airway clearance on exacerbation rates, quality of life, hospitalizations, or mortality. CONCLUSIONS: Although the cough panel was not able to make recommendations, they have made consensus-based suggestions and provided direction for future studies to fill the gaps in knowledge.
BACKGROUND: In bronchiectasis due to cystic fibrosis (CF) and other causes, airway clearance is one of the mainstays of management. We conducted a systematic review on airway clearance by using non-pharmacological methods as recommended by international guidelines to develop recommendations or suggestions to update the 2006 CHEST guideline on cough. METHODS: The systematic search for evidence examined the question, "Is there evidence of clinically important treatment effects for non-pharmacological therapies in cough treatment for patients with bronchiectasis?" Populations selected were all patients with bronchiectasis due to CF or non-CF bronchiectasis. The interventions explored were the non-pharmacological airway clearance therapies. The comparison populations included those receiving standard therapy and/or placebo. Clinically important outcomes that were explored were exacerbation rates, quality of life, hospitalizations, and mortality. RESULTS: In both CF and non-CF bronchiectasis, there were systematic reviews and overviews of systematic reviews identified. Despite these findings, there were no large randomized controlled trials that explored the impact of airway clearance on exacerbation rates, quality of life, hospitalizations, or mortality. CONCLUSIONS: Although the cough panel was not able to make recommendations, they have made consensus-based suggestions and provided direction for future studies to fill the gaps in knowledge.
Authors: Maggie Patricia McIlwaine; Nancy Alarie; George F Davidson; Larry C Lands; Felix Ratjen; Ruth Milner; Blythe Owen; Jennifer L Agnew Journal: Thorax Date: 2013-02-13 Impact factor: 9.139
Authors: Eloisa M G Regueiro; Chris Burtin; Paul Baten; Daniel Langer; Hans Van Remoortel; Valéria A Pires Di Lorenzo; Dirceu Costa; Wim Janssens; Marc Decramer; Rik Gosselink; Thierry Troosters Journal: Respir Res Date: 2013-05-25
Authors: Ashwin Basavaraj; Radmila Choate; Doreen Addrizzo-Harris; Timothy R Aksamit; Alan Barker; Charles L Daley; M Leigh Anne Daniels; Edward Eden; Angela DiMango; Kevin Fennelly; David E Griffith; Margaret M Johnson; Michael R Knowles; Mark L Metersky; Peadar G Noone; Anne E O'Donnell; Kenneth N Olivier; Matthias A Salathe; Andreas Schmid; Byron Thomashow; Gregory Tino; Kevin L Winthrop Journal: Chest Date: 2020-07-03 Impact factor: 9.410
Authors: Tara Lynn Barto; Diego Jose Maselli; Sarah Daignault; John Stiglich; Jared Porter; Carlye Kraemer; Gary Hansen Journal: Ther Adv Respir Dis Date: 2020 Jan-Dec Impact factor: 4.031
Authors: Maria Pia Riccio; Melissa Borrelli; Maria Teresa Fioretti; Margherita Del Bene; Carmela Bravaccio; Marco Poeta; Francesca Santamaria Journal: Int J Environ Res Public Health Date: 2020-11-03 Impact factor: 3.390