Literature DB >> 29355010

Sustainable Radical Cascades to Synthesize Difluoroalkylated Pyrrolo[1,2-a]indoles.

Honggui Huang1, Menglin Yu1, Xiaolong Su1, Peng Guo1, Jia Zhao1, Jiabing Zhou1, Yi Li1.   

Abstract

We disclose herein a photocatalytic difluoroalkylation and cyclization cascade reaction of N-(but-2-enoyl)indoles with broad substrate scopes in up to 90% isolated yield. This method provides sustainable and efficient access to synthesize difluoroalkylated pyrrolo[1,2-a]indoles with a quaternary carbon center under mild conditions.

Entities:  

Year:  2018        PMID： 29355010     DOI： 10.1021/acs.joc.7b03017

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

1.  Excited-State Copper Catalysis for the Synthesis of Heterocycles.

Authors:  Arghya Banerjee; Satavisha Sarkar; Jagrut A Shah; Nicoline C Frederiks; Emmanuel A Bazan-Bergamino; Christopher J Johnson; Ming-Yu Ngai
Journal:  Angew Chem Int Ed Engl       Date:  2021-12-07       Impact factor: 15.336

Review 2.  Progress in Difluoroalkylation of Organic Substrates by Visible Light Photoredox Catalysis.

Authors:  Agostinho Lemos; Christian Lemaire; André Luxen
Journal:  Adv Synth Catal       Date:  2019-01-17       Impact factor: 5.837

3.  Visible-Light-Mediated Heterocycle Functionalization via Geometrically Interrupted [2+2] Cycloaddition.

Authors:  Mihai V Popescu; Aroonroj Mekereeya; Juan V Alegre-Requena; Robert S Paton; Martin D Smith
Journal:  Angew Chem Int Ed Engl       Date:  2020-10-08       Impact factor: 15.336
  3 in total

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