Literature DB >> 29354670

Effect of Roflumilast on Airway Blood Flow in COPD: A Pilot Study.

Eliana S Mendes1, Patricia Rebolledo1, Lilian Cadet1, Johana Arana1, Andreas Scmid1, Adam Wanner1.   

Abstract

Keywords:  airway blood flow; beta2-adrenergic vasodilation; chronic obstructive pulmonary disease; copd; roflumilast

Year:  2017        PMID： 29354670      PMCID： PMC5764839          DOI： 10.15326/jcopdf.4.4.2017.0151

Source DB:  PubMed          Journal:  Chronic Obstr Pulm Dis        ISSN： 2372-952X


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  11 in total

Review 1.  Airway endothelial dysfunction in asthma and chronic obstructive pulmonary disease: a challenge for future research.

Authors:  Adam Wanner; Eliana S Mendes
Journal:  Am J Respir Crit Care Med       Date:  2010-08-13       Impact factor: 21.405

2.  Ibudilast, a mixed PDE3/4 inhibitor, causes a selective and nitric oxide/cGMP-independent relaxation of the intracranial vertebrobasilar artery.

Authors:  Takanobu Yamazaki; Tsuyoshi Anraku; Shigeki Matsuzawa
Journal:  Eur J Pharmacol       Date:  2010-10-29       Impact factor: 4.432

3.  Regulation of 3',5'-cAMP in preglomerular smooth muscle and endothelial cells from genetically hypertensive rats.

Authors:  Dongmei Cheng; Jin Ren; Delbert G Gillespie; Zaichuan Mi; Edwin K Jackson
Journal:  Hypertension       Date:  2010-10-25       Impact factor: 10.190

4.  β2-Agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteers.

Authors:  Kyoko Niimi; Qi Ge; Lyn M Moir; Alaina J Ammit; Thomas Trian; Janette K Burgess; Judith L Black; Brian G G Oliver
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2011-11-18       Impact factor: 5.464

5.  Airway blood flow reactivity in healthy smokers and in ex-smokers with or without COPD.

Authors:  Eliana S Mendes; Michael A Campos; Adam Wanner
Journal:  Chest       Date:  2006-04       Impact factor: 9.410

6.  A simplified noninvasive method to measure airway blood flow in humans.

Authors:  Adam Wanner; Eliana S Mendes; Neal D Atkins
Journal:  J Appl Physiol (1985)       Date:  2006-05

7.  Effect of the mixed phosphodiesterase 3/4 inhibitor RPL554 on human isolated bronchial smooth muscle tone.

Authors:  Luigino Calzetta; Clive P Page; Domenico Spina; Mario Cazzola; Paola Rogliani; Francesco Facciolo; Maria Gabriella Matera
Journal:  J Pharmacol Exp Ther       Date:  2013-06-13       Impact factor: 4.030

8.  Modulation of spasmogen-stimulated Ins(1,4,5)P3 generation and functional responses by selective inhibitors of types 3 and 4 phosphodiesterase in airways smooth muscle.

Authors:  R A Challiss; D Adams; R Mistry; C D Nicholson
Journal:  Br J Pharmacol       Date:  1998-05       Impact factor: 8.739

9.  cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.

Authors:  Soni Savai Pullamsetti; Rajkumar Savai; Martina Barbara Schaefer; Jochen Wilhelm; Hossein Ardeschir Ghofrani; Norbert Weissmann; Christian Schudt; Ingrid Fleming; Konstantin Mayer; James Leiper; Werner Seeger; Friedrich Grimminger; Ralph Theo Schermuly
Journal:  Circulation       Date:  2011-03-07       Impact factor: 29.690

10.  β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D.

Authors:  Thomas Trian; Janette K Burgess; Kyoko Niimi; Lyn M Moir; Qi Ge; Patrick Berger; Stephen B Liggett; Judith L Black; Brian G Oliver
Journal:  PLoS One       Date:  2011-05-17       Impact factor: 3.240
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  1 in total

Review 1.  Pharmacological mechanism of roflumilast in the treatment of asthma-COPD overlap.

Authors:  Xiaoli Zhang; Yuqing Chen; Liyu Fan; Jiaqi Ye; Junsheng Fan; Xinjie Xu; Danming You; Sihan Liu; Xin Chen; Peng Luo
Journal:  Drug Des Devel Ther       Date:  2018-08-01       Impact factor: 4.162
  1 in total

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