Literature DB >> 29354171

The challenge of nonunion after osteosynthesis of the clavicle: is it a biomechanical or infection problem?

Giuseppe Rollo1, Paolo Pichierri1, Antonio Marsilio1, Marco Filipponi1, Michele Bisaccia2, Luigi Meccariello1.   

Abstract

INTRODUCTION: The nonunion rate has been reported between 0.1% and 15%. There are also several predisposing factors for the onset of complications: general factors connected with the patient and specific factors related to the fracture site. The purpose of our study is to review the etiology of nonunion of the clavicle in its atrophic form and investigate the outcomes of the revision treatment in a single step.
MATERIALS AND METHODS: Retrospective study on 71 patients suffering from nonunions due to the following treatments: conservative in 13 patients; plate fixation in 12; closed reduction and fixation with K-wire in 24; open reduction and fixation with K-wire. All patients were operated on in beach chair position and classic approach to the clavicle by incising the previous surgical scar. The clinical and radiographic criteria for evaluating the outcomes were: the Short Form (12) Health Survey (SF-12), the Constant Shoulder Score (CSS) and the Disability Disabilities of the Arm, Shoulder and Score (DASH) and radiographic Union Score (RUS) for bone healing. The evaluation endpoint was set at 12 months.
RESULTS: Blood and culture tests showed 22 infected nonunions and 49 atrophic or oligoatrophic. In only 10 cases, before surgery, the inflammatory markers were positive. The isolated microorganisms were resistant to common antibiotics. In 70 out of 71 cases, plates and screws on the upper side and fibula allogenic splints at the bottom, associated with cancellous bone grafts taken from the patients' iliac crests, were implanted. In one case, however, it was decided to implant the plate on the front edge of the clavicle and the fibula allogeneic splint on the posterior margin, also associated with a cancellous bone graft taken from the patient's iliac crest. The radiographic bone healing was observed in 107.8 (range 82-160) days for the aseptic nonunions, while in 118.4 (range 82-203) days for the septic ones. The non-healing case was a serious failure that led to asubtotal excision of the clavicle.
CONCLUSIONS: The importance of classification and study of nonunions are essential to achieve positive outcomes. The guiding principle of our work is that aseptic nonunions heal in the operating room, while infected nonunions can be challenged and defeated on the operating table. Restoring the correct length of the clavicle interconnection between the sternum and the shoulder cingulum is indispensable to avoid functional deficits of the upper limb. The fibula splint and the tricorticale bone graft have both mechanical and strong biological values to quickly heal the nonunion. The return to pre-injury quality of life has to be our main goal.

Entities:  

Keywords:  biomechanical; bone allograft; clavicle non union; infection; outcomes

Year:  2017        PMID: 29354171      PMCID: PMC5762233          DOI: 10.11138/ccmbm/2017.14.3.372

Source DB:  PubMed          Journal:  Clin Cases Miner Bone Metab        ISSN: 1724-8914


  33 in total

1.  Validation of the Non-Union Scoring System in 300 long bone non-unions.

Authors:  G M Calori; M Colombo; E L Mazza; S Mazzola; E Malagoli; N Marelli; A Corradi
Journal:  Injury       Date:  2014-10-29       Impact factor: 2.586

Review 2.  The evidence base for the efficacy of antibiotic prophylaxis in dental practice.

Authors:  Peter B Lockhart; Bridget Loven; Michael T Brennan; Philip C Fox
Journal:  J Am Dent Assoc       Date:  2007-04       Impact factor: 3.634

3.  [Treatment of mid-clavicular fractures in adults. Early results after rucksack bandage or elastic stable intramedullary nailing].

Authors:  A Jubel; J Andermahr; A Prokop; J I Lee; G Schiffer; K E Rehm
Journal:  Unfallchirurg       Date:  2005-09       Impact factor: 1.000

4.  Anteroinferior plating of midshaft clavicle nonunions and fractures.

Authors:  Peter Kloen; Clément M L Werner; Sjoerd A S Stufkens; David L Helfet
Journal:  Oper Orthop Traumatol       Date:  2009-06       Impact factor: 1.154

Review 5.  Clinical guidelines for the antimicrobial treatment of bone and joint infections in Korea.

Authors: 
Journal:  Infect Chemother       Date:  2014-06-20

6.  Plating versus intramedullary fixation for mid-shaft clavicle fractures: a systemic review and meta-analysis.

Authors:  Yan Gao; Wei Chen; Yue-Jv Liu; Xu Li; Hai-Li Wang; Zhao-Yu Chen
Journal:  PeerJ       Date:  2016-02-22       Impact factor: 2.984

7.  Management of mid-shaft clavicular fractures: comparison between non-operative treatment and plate fixation in 60 patients.

Authors:  B M Naveen; G R Joshi; B Harikrishnan
Journal:  Strategies Trauma Limb Reconstr       Date:  2017-01-04

8.  Feasibility and Value of Radiographic Union Score Hip Fracture after Treatment with Intramedullary Nail of Stable Hip Fractures.

Authors:  Daniele Maiettini; Michele Bisaccia; Auro Caraffa; Giuseppe Rinonapoli; Luigi Piscitelli; Olga Bisaccia; Giuseppe Rollo; Luigi Meccariello; Paolo Ceccarini; Alberto Rebonato
Journal:  Acta Inform Med       Date:  2016-12

9.  Does plate type influence the clinical outcomes and implant removal in midclavicular fractures fixed with 2.7-mm anteroinferior plates? A retrospective cohort study.

Authors:  Alex K Gilde; Clifford B Jones; Debra L Sietsema; Martin F Hoffmann
Journal:  J Orthop Surg Res       Date:  2014-07-04       Impact factor: 2.359

10.  Plate fixation versus intramedullary fixation for midshaft clavicle fractures: Meta-analysis of complications and functional outcomes.

Authors:  Hao Xiao; Hengbo Gao; Tuokang Zheng; Jianhui Zhao; Yingping Tian
Journal:  J Int Med Res       Date:  2016-02-15       Impact factor: 1.671

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1.  Surgical Treatment of Clavicular Fractures, Refractures, Delayed and Non-Unions Using a Resorbable, Gentamicin-Eluting Calcium Sulphate/Hydroxyapatite Biocomposite.

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2.  Grafting and fixation after aseptic non-union of the humeral shaft: A case series.

Authors:  Giuseppe Rollo; Ante Prkic; Michele Bisaccia; Denise Eygendaal; Paolo Pichierri; Antonio Marsilio; Marco Giaracuni; Luigi Meccariello
Journal:  J Clin Orthop Trauma       Date:  2019-08-31

3.  Plate-and-bone-strut fixation of distal third humeral shaft aseptic non-unions: A consecutive case series.

Authors:  Giuseppe Rollo; Ante Prkić; Paolo Pichierri; Denise Eygendaal; Michele Bisaccia; Marco Filipponi; Marco Giaracuni; Philip Hitov; Kostadin Tanovski; Luigi Meccariello
Journal:  J Clin Orthop Trauma       Date:  2019-05-07

4.  Vitamin C May Help to Reduce the Knee's Arthritic Symptoms. Outcomes Assessment of Nutriceutical Therapy.

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Journal:  Med Arch       Date:  2019-06

5.  Bilaterally Threaded, Minimal Invasive, Elastic Locking Intramedullary Nailing (ELIN) for the Treatment of Clavicle Fractures.

Authors:  Kifayat Ullah; Saima Khan; Yong-Qing Wang; Zhi-Hui Zhao; Peng Cheng; Basanta Sapkota; Liang Ren; Samiullah Khan; Mujeeb Ur Rehman; Yuan Xue
Journal:  Orthop Surg       Date:  2020-02       Impact factor: 2.071

6.  Safe and Effective Treatment of Compromised Clavicle Fracture of the Medial and Lateral Third Using Focused Shockwaves.

Authors:  Rainer Mittermayr; Nicolas Haffner; Sebastian Eder; Jonas Flatscher; Wolfgang Schaden; Paul Slezak; Cyrill Slezak
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7.  Comparison of the Effectiveness of Simple Plate Fixation and Plate Combined with Local Fixation of Broken Ends in the Treatment of Oblique Fracture of Midshaft Clavicle.

Authors:  Gong-Ming Gao; Yi Zhang; Hai-Bo Li; Lu-Ming Nong; Xin-Die Zhou; Wei Jiang; Long Han
Journal:  Orthop Surg       Date:  2022-05-23       Impact factor: 2.279

8.  Treatment of unstable distal clavicle fractures (Neer type IIb): a modified system using a miniature locking plate with a single button.

Authors:  Hua Ying; Jihuan Wang; Yuehua Sun; Kerong Dai; Chao Yu; Fei Yang
Journal:  J Int Med Res       Date:  2021-06       Impact factor: 1.671

9.  Medial Femoral Condyle Vascularized Bone Graft for Treatment of Midshaft Clavicle Recalcitrant Nonunion With Use of the Transverse Cervical Artery as an Anastomosis.

Authors:  Christopher M Belyea; Jefferson L Lansford; Joseph B Golden; Emily H Shin; Rey D L Gumboc
Journal:  J Am Acad Orthop Surg Glob Res Rev       Date:  2020-06-01

10.  Open Reduction and Internal Fixation Using Double Plating with Biological and Artificial Bone Grafting of Aseptic Non-unions of the Distal Humerus: Clinical Results.

Authors:  Giuseppe Rollo; Giovanni Vicenti; Roberto Rotini; Ante Prkic; Denise Eygendaal; Luigi Meccariello
Journal:  Strategies Trauma Limb Reconstr       Date:  2021 Sep-Dec
  10 in total

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