Literature DB >> 29352051

Long-Term Cognitive Functioning in Testicular Germ-Cell Tumor Survivors.

Michal Chovanec1,2,3, Lucia Vasilkova4,3, Lucia Setteyova5, Jana Obertova1,3, Patrik Palacka1,3, Katarina Rejlekova1,3, Zuzana Sycova-Mila3, Katarina Kalavska2, Daniela Svetlovska2, Silvia Cingelova2, Beata Mladosievicova5, Jozef Mardiak1,3, Michal Mego6,2,3.   

Abstract

BACKGROUND: Treatment for cancer may lead to development of cognitive difficulties in cancer survivors. This study aimed to evaluate long-term cognitive functioning (CogF) in germ-cell tumor (GCT) survivors. SUBJECTS, MATERIALS, AND METHODS: GCT survivors (n = 155) from the National Cancer Institute of Slovakia completed the Functional Assessment of Cancer Therapy Cognitive Function at a median of 10 years of follow-up (range: 5-32). The study group consisted of survivors receiving a cisplatin-based chemotherapy, radiotherapy to the retroperitoneal lymph nodes, or both, whereas the control group included survivors treated with orchiectomy only.
RESULTS: Of the total survivors, 138 received treatment beyond orchiectomy and 17 controls had orchiectomy alone. Any treatment resulted in significantly greater cognitive difficulties on the overall cognitive function score. Treatment with radiotherapy was associated with cognitive declines in overall cognitive functioning and in subscales for perceived cognitive impairment and cognitive impairment perceived by others (both p < .05). The burden of chemotherapy plus radiotherapy or radiotherapy versus controls resulted in the impairment in all cognitive functioning domains (all p < .05). Overall long-term cognitive impairment was independent of age in the multivariable analysis.
CONCLUSION: This prospective study shows that GCT survivors suffer from a long-term CogF impairment. These results may help guide clinicians' decisions in treatment and follow-up of GCTs. IMPLICATIONS FOR PRACTICE: In this study, long-term survivors of germ-cell tumors have reported cognitive impairment after curative treatment with radiotherapy and chemotherapy compared with controls who had treatment with orchiectomy only. These data provide an argument against the use of adjuvant radiotherapy for stage I seminoma. Unnecessary overtreatment with chemotherapy and additional radiotherapy after chemotherapy should be avoided. © AlphaMed Press 2018.

Entities:  

Keywords:  Chemotherapy; Cognitive functioning; Late toxicity; Long‐term; Radiotherapy; Survivors; Testicular germ‐cell tumors

Mesh：

Year:  2018        PMID： 29352051      PMCID： PMC5947452          DOI： 10.1634/theoncologist.2017-0457

Source DB:  PubMed          Journal:  Oncologist        ISSN： 1083-7159


  25 in total

1.  Changes in cognitive functions and cerebral grey matter and their associations with inflammatory markers, endocrine markers, and APOE genotypes in testicular cancer patients undergoing treatment.

Authors:  Ali Amidi; Mads Agerbæk; Lisa M Wu; Anders D Pedersen; Mimi Mehlsen; Cecilie R Clausen; Ditte Demontis; Anders D Børglum; Anja Harbøll; Robert Zachariae
Journal:  Brain Imaging Behav       Date:  2017-06       Impact factor: 3.978

2.  Testicular cancer: a reflection on 50 years of discovery.

Authors:  Nasser Hanna; Lawrence H Einhorn
Journal:  J Clin Oncol       Date:  2014-07-14       Impact factor: 44.544

3.  A prospective study of cognitive function in men with non-seminomatous germ cell tumors.

Authors:  Jeffrey S Wefel; Damon J Vidrine; Salma K Marani; Richard J Swartz; Tracy L Veramonti; Christina A Meyers; Harald J Hoekstra; Josette E H M Hoekstra-Weebers; Ellen R Gritz
Journal:  Psychooncology       Date:  2013-12-16       Impact factor: 3.894

4.  Paclitaxel plus ifosfamide and cisplatin in second-line treatment of germ cell tumors: a phase II study.

Authors:  J Mardiak; T Sálek; Z Sycová-Milá; J Obertová; Z Hlavatá; M Mego; M Recková; I Koza
Journal:  Neoplasma       Date:  2005       Impact factor: 2.575

5.  Health-related quality of life in the general Norwegian population assessed by the European Organization for Research and Treatment of Cancer Core Quality-of-Life Questionnaire: the QLQ=C30 (+ 3).

Authors:  M J Hjermstad; P M Fayers; K Bjordal; S Kaasa
Journal:  J Clin Oncol       Date:  1998-03       Impact factor: 44.544

6.  Cognitive impairment in testicular cancer survivors 2 to 7 years after treatment.

Authors:  Ali Amidi; Lisa M Wu; Anders Degn Pedersen; Mimi Mehlsen; Christina Gundgaard Pedersen; Philip Rossen; Mads Agerbæk; Robert Zachariae
Journal:  Support Care Cancer       Date:  2015-02-26       Impact factor: 3.603

7.  Treatment of testicular cancer: a new and improved model.

Authors:  L H Einhorn
Journal:  J Clin Oncol       Date:  1990-11       Impact factor: 44.544

8.  Personality traits and psychosocial stress: quality of life over 2 years following breast cancer diagnosis and psychological impact factors.

Authors:  Kristin Härtl; Jutta Engel; Peter Herschbach; Hans Reinecker; Harald Sommer; Klaus Friese
Journal:  Psychooncology       Date:  2010-02       Impact factor: 3.894

9.  Long-term and late effects of germ cell testicular cancer treatment and implications for follow-up.

Authors:  Hege S Haugnes; George J Bosl; Hink Boer; Jourik A Gietema; Marianne Brydøy; Jan Oldenburg; Alv A Dahl; Roy M Bremnes; Sophie D Fosså
Journal:  J Clin Oncol       Date:  2012-09-24       Impact factor: 44.544

10.  The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology.

Authors:  N K Aaronson; S Ahmedzai; B Bergman; M Bullinger; A Cull; N J Duez; A Filiberti; H Flechtner; S B Fleishman; J C de Haes
Journal:  J Natl Cancer Inst       Date:  1993-03-03       Impact factor: 13.506
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  9 in total

1.  Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments.

Authors:  Ki Hyun Yoo; Jason J Tang; Mohammad Abdur Rashid; Chang Hoon Cho; Ana Corujo-Ramirez; Jonghoon Choi; Mun Gyeong Bae; Danielle Brogren; John R Hawse; Xiaonan Hou; S John Weroha; Alfredo Oliveros; Lindsey A Kirkeby; Joseph A Baur; Mi-Hyeon Jang
Journal:  Cancer Res       Date:  2021-03-26       Impact factor: 12.701

2.  Testicular cancer follow-up costs in Germany from 2000 to 2015.

Authors:  Thomas Michaeli; Julia Michaeli; Daniel Michaeli
Journal:  J Cancer Res Clin Oncol       Date:  2021-04-22       Impact factor: 4.553

Review 3.  Caregiver Emotional Burden in Testicular Cancer Patients: From Patient to Caregiver Support.

Authors:  Silvia De Padova; Chiara Casadei; Alejandra Berardi; Tatiana Bertelli; Alessia Filograna; Maria Concetta Cursano; Cecilia Menna; Salvatore Luca Burgio; Amelia Altavilla; Giuseppe Schepisi; Sabrina Prati; Sandra Montalti; Michal Chovanec; Giuseppe Luigi Banna; Luigi Grassi; Michal Mego; Ugo De Giorgi
Journal:  Front Endocrinol (Lausanne)       Date:  2019-05-28       Impact factor: 5.555

Review 4.  Long-Term Cognitive Dysfunction in Cancer Survivors.

Authors:  Zuzana Országhová; Michal Mego; Michal Chovanec
Journal:  Front Mol Biosci       Date:  2021-12-14

5.  Novel sequential therapy with metformin enhances the effects of cisplatin in testicular germ cell tumours via YAP1 signalling.

Authors:  Kancheng He; Zitaiyu Li; Kun Ye; Yihong Zhou; Minbo Yan; Hao Qi; Huating Hu; Yingbo Dai; Yuxin Tang
Journal:  Cancer Cell Int       Date:  2022-03-09       Impact factor: 5.722

6.  Effects of primary granulocyte-colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with germ cell tumors.

Authors:  Nikola Hapakova; Michal Chovanec; Katarina Rejlekova; Katarina Kalavska; Jana Obertova; Patrik Palacka; Valentina De Angelis; Daniela Svetlovska; Zuzana Sycova-Mila; Jozef Mardiak; Michal Mego
Journal:  Oncol Lett       Date:  2022-07-13       Impact factor: 3.111

Review 7.  Late adverse effects and quality of life in survivors of testicular germ cell tumour.

Authors:  Michal Chovanec; Jakob Lauritsen; Mikkel Bandak; Christoph Oing; Gry Gundgaard Kier; Michael Kreiberg; Josephine Rosenvilde; Thomas Wagner; Carsten Bokemeyer; Gedske Daugaard
Journal:  Nat Rev Urol       Date:  2021-03-08       Impact factor: 14.432

Review 8.  An Overview on Chemotherapy-induced Cognitive Impairment and Potential Role of Antidepressants.

Authors:  Ankit Das; Niraja Ranadive; Manas Kinra; Madhavan Nampoothiri; Devinder Arora; Jayesh Mudgal
Journal:  Curr Neuropharmacol       Date:  2020       Impact factor: 7.363

9.  Long-term sexual functioning in germ-cell tumor survivors.

Authors:  M Chovanec; L Vasilkova; L Petrikova; J Obertova; P Palacka; K Rejlekova; Z Sycova-Mila; K Kalavska; D Svetlovska; B Mladosievicova; J Mardiak; M Mego
Journal:  BMC Cancer       Date:  2020-08-20       Impact factor: 4.430
  9 in total

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