Literature DB >> 29351839

Activating and Repressing IRE1α: The Hsp47 and BiP Tug of War.

Lydia Lamriben1, Daniel N Hebert2.   

Abstract

In this issue of Molecular Cell, Sepulveda et al. (2018) discovered an interesting role of Hsp47 in regulating the unfolded protein response (UPR) wherein Hsp47 binds to IRE1α and displaces BiP, thereby activating the IRE1α arm of the UPR pathway by a previously undetermined mechanism.
Copyright © 2018 Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 29351839      PMCID： PMC6816461          DOI： 10.1016/j.molcel.2017.12.032

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  9 in total

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Authors:  Peter Walter; David Ron
Journal:  Science       Date:  2011-11-25       Impact factor: 47.728

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Authors:  Claudio Hetz; Feroz R Papa
Journal:  Mol Cell       Date:  2017-11-05       Impact factor: 17.970

Review 3.  Biology of Hsp47 (Serpin H1), a collagen-specific molecular chaperone.

Authors:  Shinya Ito; Kazuhiro Nagata
Journal:  Semin Cell Dev Biol       Date:  2016-11-09       Impact factor: 7.727

4.  An unfolded protein-induced conformational switch activates mammalian IRE1.

Authors:  G Elif Karagöz; Diego Acosta-Alvear; Hieu T Nguyen; Crystal P Lee; Feixia Chu; Peter Walter
Journal:  Elife       Date:  2017-10-03       Impact factor: 8.140

5.  A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis.

Authors:  Shinya Ito; Koji Ogawa; Koh Takeuchi; Motoki Takagi; Masahito Yoshida; Takatsugu Hirokawa; Shoshiro Hirayama; Kazuo Shin-Ya; Ichio Shimada; Takayuki Doi; Naoki Goshima; Tohru Natsume; Kazuhiro Nagata
Journal:  J Biol Chem       Date:  2017-10-12       Impact factor: 5.157

6.  pH-dependent function, purification, and intracellular location of a major collagen-binding glycoprotein.

Authors:  S Saga; K Nagata; W T Chen; K M Yamada
Journal:  J Cell Biol       Date:  1987-07       Impact factor: 10.539

7.  Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling.

Authors:  Marta Carrara; Filippo Prischi; Piotr R Nowak; Megan C Kopp; Maruf Mu Ali
Journal:  Elife       Date:  2015-02-18       Impact factor: 8.140

8.  A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response.

Authors:  Niko Amin-Wetzel; Reuben A Saunders; Maarten J Kamphuis; Claudia Rato; Steffen Preissler; Heather P Harding; David Ron
Journal:  Cell       Date:  2017-11-30       Impact factor: 41.582

9.  The endoplasmic reticulum-resident chaperone heat shock protein 47 protects the Golgi apparatus from the effects of O-glycosylation inhibition.

Authors:  Shingo Miyata; Tatsunori Mizuno; Yoshihisa Koyama; Taiichi Katayama; Masaya Tohyama
Journal:  PLoS One       Date:  2013-07-29       Impact factor: 3.240
  9 in total
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Review 3.  IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis.

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Journal:  J Cell Physiol       Date:  2021-07-23       Impact factor: 6.513

Review 4.  Protein Quality Control in the Endoplasmic Reticulum and Cancer.

Authors:  Hye Won Moon; Hye Gyeong Han; Young Joo Jeon
Journal:  Int J Mol Sci       Date:  2018-10-03       Impact factor: 5.923
  4 in total

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