H Zhang1, A Kaushal1, N Soto-Ramírez2, A H Ziyab3, S Ewart4, J W Holloway5,6, W Karmaus1, H Arshad5,7. 1. Division of Epidemiology, Biostatistics, and Environmental Health Sciences, School of Public Health, University of Memphis, Memphis, TN, USA. 2. College of Social Work, University of South Carolina, Columbia, SC, USA. 3. Department of Community Medicine and Behavioral Sciences, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait. 4. College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA. 5. Clinical and Experimental Medicine, Faculty of Medicine, University of Southampton, Southampton, UK. 6. Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK. 7. David Hide Asthma and Allergy Research Centre, Isle of Wight, UK.
Abstract
BACKGROUND: Allergic sensitization is associated with eczema, asthma, and rhinitis. However, it is unknown whether and how allergic sensitization is associated over time with acquisition, remission, and persistence of these diseases and their comorbidity. OBJECTIVE: To gain a better understanding of factors including allergic sensitization transitions that influence the temporal pattern of asthma, eczema, and rhinitis and their comorbidity during childhood. METHODS: In the Isle of Wight birth cohort, information on allergic sensitization to common allergens was collected at ages 4, 10, and 18 years along with asthma, rhinitis, and eczema status determined by clinical diagnosis. Logistic regressions were used to estimate subsequent and concurrent odds ratios of diseases transition with allergic sensitization transition status as the main independent variable. Two transition periods were considered, 4 to 10 years of age and 10 to 18 years of age. RESULTS: The odds of new diagnosis of allergic disease (no-yes) was increased among subjects with acquired or persistent allergic sensitization to common allergens compared to subjects with no sensitization (acquisition of sensitization odds ratio [OR]=3.22, P < .0001; persistence of sensitization, OR=6.33, P < .0001). The odds of remission of allergic diseases (yes-no) was lower among subjects with acquired or sustained allergic sensitization (acquisition, OR=0.18, P = .0001; persistence, OR=0.085, P < .0001), compared to subjects not sensitized. Subjects with acquired or persistent allergic sensitization were also had higher odds for persistence of disease (yes-yes) than subjects not sensitized (acquisition, OR=5.49, P = .0001; persistence, OR=11.79, P < .0001). CONCLUSION: Transition of allergic sensitizations to common allergens is a prognostic factor for subsequent or concurrent transition of eczema, asthma, and rhinitis. Prevention or reduction in allergic sensitization has a potential to lead to remission of these conditions.
BACKGROUND:Allergic sensitization is associated with eczema, asthma, and rhinitis. However, it is unknown whether and how allergic sensitization is associated over time with acquisition, remission, and persistence of these diseases and their comorbidity. OBJECTIVE: To gain a better understanding of factors including allergic sensitization transitions that influence the temporal pattern of asthma, eczema, and rhinitis and their comorbidity during childhood. METHODS: In the Isle of Wight birth cohort, information on allergic sensitization to common allergens was collected at ages 4, 10, and 18 years along with asthma, rhinitis, and eczema status determined by clinical diagnosis. Logistic regressions were used to estimate subsequent and concurrent odds ratios of diseases transition with allergic sensitization transition status as the main independent variable. Two transition periods were considered, 4 to 10 years of age and 10 to 18 years of age. RESULTS: The odds of new diagnosis of allergic disease (no-yes) was increased among subjects with acquired or persistent allergic sensitization to common allergens compared to subjects with no sensitization (acquisition of sensitization odds ratio [OR]=3.22, P < .0001; persistence of sensitization, OR=6.33, P < .0001). The odds of remission of allergic diseases (yes-no) was lower among subjects with acquired or sustained allergic sensitization (acquisition, OR=0.18, P = .0001; persistence, OR=0.085, P < .0001), compared to subjects not sensitized. Subjects with acquired or persistent allergic sensitization were also had higher odds for persistence of disease (yes-yes) than subjects not sensitized (acquisition, OR=5.49, P = .0001; persistence, OR=11.79, P < .0001). CONCLUSION: Transition of allergic sensitizations to common allergens is a prognostic factor for subsequent or concurrent transition of eczema, asthma, and rhinitis. Prevention or reduction in allergic sensitization has a potential to lead to remission of these conditions.
Authors: T Keil; A Bockelbrink; A Reich; U Hoffmann; W Kamin; J Forster; A Schuster; S N Willich; U Wahn; S Lau Journal: Pediatr Allergy Immunol Date: 2010-05-09 Impact factor: 6.377
Authors: J Bousquet; J M Anto; M Wickman; T Keil; R Valenta; T Haahtela; K Lodrup Carlsen; M van Hage; C Akdis; C Bachert; M Akdis; C Auffray; I Annesi-Maesano; C Bindslev-Jensen; A Cambon-Thomsen; K H Carlsen; L Chatzi; F Forastiere; J Garcia-Aymerich; U Gehrig; S Guerra; J Heinrich; G H Koppelman; M L Kowalski; B Lambrecht; C Lupinek; D Maier; E Melén; I Momas; S Palkonen; M Pinart; D Postma; V Siroux; H A Smit; J Sunyer; J Wright; T Zuberbier; S H Arshad; R Nadif; C Thijs; N Andersson; A Asarnoj; N Ballardini; S Ballereau; A Bedbrook; M Benet; A Bergstrom; B Brunekreef; E Burte; M Calderon; G De Carlo; P Demoly; E Eller; M P Fantini; H Hammad; C Hohman; J Just; M Kerkhof; M Kogevinas; I Kull; S Lau; N Lemonnier; M Mommers; M Nawijn; A Neubauer; S Oddie; J Pellet; I Pin; D Porta; Y Saes; I Skrindo; C G Tischer; M Torrent; L von Hertzen Journal: Allergy Date: 2015-07-14 Impact factor: 13.146
Authors: Aniruddha Rathod; Hongmei Zhang; Syed Hasan Arshad; Susan Ewart; Caroline L Relton; Wilfried Karmaus; John W Holloway Journal: J Pers Med Date: 2022-02-02