Ayman Samman Tahhan1, Muthiah Vaduganathan2, Stephen J Greene3, Maureen Okafor4, Sonali Kumar4, Javed Butler5. 1. Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA, USA. 2. Brigham and Women's Hospital Heart & Vascular Center and Harvard Medical School, Boston, MA, USA. 3. Duke Clinical Research Institute and Division of Cardiology, Duke University Medical Center, Durham, NC, USA. 4. Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. 5. Division of Cardiology, Health Sciences Center, Stony Brook University, T-16, Room 080, SUNY, Stony Brook, NY, 11794, USA. javed.butler@stonybrookmedicine.edu.
Abstract
PURPOSE OF REVIEW: Clinical trial design and execution are evolving as increasingly important considerations with respect to the success of heart failure trials. The current review highlights temporal trends in characteristics of heart failure clinical trials. RECENT FINDINGS: Recent trials in heart failure have required longer recruitment phases, displayed inefficient enrollment rates, increased use of composite and nonfatal endpoints, undergone rapid globalization, and gradually increased focus on heart failure with preserved ejection fraction. Understanding patterns and trends in clinical trial design and execution may inform future planning and conduct of trials of heart failure therapeutics.
PURPOSE OF REVIEW: Clinical trial design and execution are evolving as increasingly important considerations with respect to the success of heart failure trials. The current review highlights temporal trends in characteristics of heart failure clinical trials. RECENT FINDINGS: Recent trials in heart failure have required longer recruitment phases, displayed inefficient enrollment rates, increased use of composite and nonfatal endpoints, undergone rapid globalization, and gradually increased focus on heart failure with preserved ejection fraction. Understanding patterns and trends in clinical trial design and execution may inform future planning and conduct of trials of heart failure therapeutics.
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