Sertaç Yakal1, Sevtün Sofyalı1, Berker Özkan2, Safinaz Yıldız1, Alper Toker2, Erdem Kasikcioglu3. 1. Department of Sports Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. 2. Department of Chest Surgery, Istanbul University, Istanbul, Turkey. 3. Department of Sports Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. ekasikcioglu@yahoo.com.
Abstract
OBJECTIVE: Peak oxygen consumption is a very valuable cardiopulmonary functional parameter in pre-operative evaluation of patients with lung cancer. However, it has several critical limitations for operability decision due to failure in achieving maximal level of exercise test for cases. The aim of this study was to reveal the importance of more accurate cardiopulmonary parameters that can be calculated from data of submaximal level test, such as oxygen uptake efficiency slope (OUES) and to determine whether it could be used in the operability decision phase for borderline cases by means of morbidity and mortality. MATERIALS AND METHODS: One hundred and twenty-five patients who were scheduled to undergo lung surgery due to lung cancer were included in the study. Peak oxygen uptake (pVO2), heart rate at the anaerobic threshold, and oxygen consumption volume at anaerobic threshold values were obtained after performing the cardiopulmonary exercise test. The OUES value was calculated from the ratio of the peak VO2 value and logarithmic equivalent of the ventilatory volume (VE). The following equation was used for determining OUES: VO2/log10 VE. RESULTS: The peak VO2 mean value was 21.37 ± 4.20 mL/min/kg in patients. However, OUES mean value was 12.44 ± 2.11. When the metabolic parameters of the patients were compared, a significant correlation was determined between the peak VO2 value and peak VE, OUES, and survival (p < 0.01). CONCLUSION: This study demonstrated that OUES is significantly correlated with peak VO2 and it does not require the performance of maximal exercise and can be used together with peak VO2 in this patient population when there is difficulty in making decision for surgery in patients with lung cancer.
OBJECTIVE: Peak oxygen consumption is a very valuable cardiopulmonary functional parameter in pre-operative evaluation of patients with lung cancer. However, it has several critical limitations for operability decision due to failure in achieving maximal level of exercise test for cases. The aim of this study was to reveal the importance of more accurate cardiopulmonary parameters that can be calculated from data of submaximal level test, such as oxygen uptake efficiency slope (OUES) and to determine whether it could be used in the operability decision phase for borderline cases by means of morbidity and mortality. MATERIALS AND METHODS: One hundred and twenty-five patients who were scheduled to undergo lung surgery due to lung cancer were included in the study. Peak oxygen uptake (pVO2), heart rate at the anaerobic threshold, and oxygen consumption volume at anaerobic threshold values were obtained after performing the cardiopulmonary exercise test. The OUES value was calculated from the ratio of the peak VO2 value and logarithmic equivalent of the ventilatory volume (VE). The following equation was used for determining OUES: VO2/log10 VE. RESULTS: The peak VO2 mean value was 21.37 ± 4.20 mL/min/kg in patients. However, OUES mean value was 12.44 ± 2.11. When the metabolic parameters of the patients were compared, a significant correlation was determined between the peak VO2 value and peak VE, OUES, and survival (p < 0.01). CONCLUSION: This study demonstrated that OUES is significantly correlated with peak VO2 and it does not require the performance of maximal exercise and can be used together with peak VO2 in this patient population when there is difficulty in making decision for surgery in patients with lung cancer.
Authors: C T Bolliger; M Solèr; P Stulz; E Grädel; J Müller-Brand; S Elsasser; M Gonon; C Wyser; A P Perruchoud Journal: Respiration Date: 1994 Impact factor: 3.580
Authors: J Ribas; O Díaz; J A Barberà; M Mateu; E Canalís; L Jover; J Roca; R Rodriguez-Roisin Journal: Eur Respir J Date: 1998-12 Impact factor: 16.671
Authors: G L Walsh; R C Morice; J B Putnam; J C Nesbitt; M J McMurtrey; M B Ryan; J M Reising; K M Willis; J D Morton; J A Roth Journal: Ann Thorac Surg Date: 1994-09 Impact factor: 4.330
Authors: Thida Win; Arlene Jackson; Ashley M Groves; Francis C Wells; Andrew J Ritchie; Helen Munday; Clare M Laroche Journal: Eur J Cardiothorac Surg Date: 2004-12 Impact factor: 4.191
Authors: Justin Heizer; Salvatore Carbone; Hayley E Billingsley; Benjamin W VAN Tassell; Ross Arena; Antonio Abbate; Justin M Canada Journal: Minerva Cardiol Angiol Date: 2020-09-30
Authors: Ruud F W Franssen; Anne J J Eversdijk; Mayella Kuikhoven; Joost M Klaase; F Jeroen Vogelaar; Maryska L G Janssen-Heijnen; Bart C Bongers Journal: BMC Anesthesiol Date: 2022-04-30 Impact factor: 2.217
Authors: Daniel Steffens; Hilmy Ismail; Linda Denehy; Paula R Beckenkamp; Michael Solomon; Cherry Koh; Jenna Bartyn; Neil Pillinger Journal: Ann Surg Oncol Date: 2021-06-08 Impact factor: 5.344