Literature DB >> 29348682

Glimmers in illuminating the druggable genome.

Griffin Rodgers1, Christopher Austin2, James Anderson3, Aaron Pawlyk4, Christine Colvis2, Ronald Margolis4, Jenna Baker4.   

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Year:  2018        PMID： 29348682      PMCID： PMC6309548          DOI： 10.1038/nrd.2017.252

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  5 in total

1.  Too many roads not taken.

Authors:  Aled M Edwards; Ruth Isserlin; Gary D Bader; Stephen V Frye; Timothy M Willson; Frank H Yu
Journal:  Nature       Date:  2011-02-10       Impact factor: 49.962

2.  PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.

Authors:  Wesley K Kroeze; Maria F Sassano; Xi-Ping Huang; Katherine Lansu; John D McCorvy; Patrick M Giguère; Noah Sciaky; Bryan L Roth
Journal:  Nat Struct Mol Biol       Date:  2015-04-20       Impact factor: 15.369

3.  Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.

Authors:  Giancarlo Bruni; Andrew J Rennekamp; Andrea Velenich; Matthew McCarroll; Leo Gendelev; Ethan Fertsch; Jack Taylor; Parth Lakhani; Dennis Lensen; Tama Evron; Paul J Lorello; Xi-Ping Huang; Sabine Kolczewski; Galen Carey; Barbara J Caldarone; Eric Prinssen; Bryan L Roth; Michael J Keiser; Randall T Peterson; David Kokel
Journal:  Nat Chem Biol       Date:  2016-05-30       Impact factor: 15.040

4.  Pharos: Collating protein information to shed light on the druggable genome.

Authors:  Dac-Trung Nguyen; Stephen Mathias; Cristian Bologa; Soren Brunak; Nicolas Fernandez; Anna Gaulton; Anne Hersey; Jayme Holmes; Lars Juhl Jensen; Anneli Karlsson; Guixia Liu; Avi Ma'ayan; Geetha Mandava; Subramani Mani; Saurabh Mehta; John Overington; Juhee Patel; Andrew D Rouillard; Stephan Schürer; Timothy Sheils; Anton Simeonov; Larry A Sklar; Noel Southall; Oleg Ursu; Dusica Vidovic; Anna Waller; Jeremy Yang; Ajit Jadhav; Tudor I Oprea; Rajarshi Guha
Journal:  Nucleic Acids Res       Date:  2016-11-29       Impact factor: 16.971

Review 5.  A comprehensive map of molecular drug targets.

Authors:  Rita Santos; Oleg Ursu; Anna Gaulton; A Patrícia Bento; Ramesh S Donadi; Cristian G Bologa; Anneli Karlsson; Bissan Al-Lazikani; Anne Hersey; Tudor I Oprea; John P Overington
Journal:  Nat Rev Drug Discov       Date:  2016-12-02       Impact factor: 84.694
  5 in total
  34 in total

1.  Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity.

Authors:  Fleur M Ferguson; Zainab M Doctor; Scott B Ficarro; Christopher M Browne; Jarrod A Marto; Jared L Johnson; Tomer M Yaron; Lewis C Cantley; Nam Doo Kim; Taebo Sim; Matthew J Berberich; Marian Kalocsay; Peter K Sorger; Nathanael S Gray
Journal:  Cell Chem Biol       Date:  2019-03-28       Impact factor: 8.116

Review 2.  Exploring the dark genome: implications for precision medicine.

Authors:  Tudor I Oprea
Journal:  Mamm Genome       Date:  2019-07-04       Impact factor: 2.957

Review 3.  The PROTACtable genome.

Authors:  Melanie Schneider; Chris J Radoux; Andrew Hercules; David Ochoa; Ian Dunham; Lykourgos-Panagiotis Zalmas; Gerhard Hessler; Sven Ruf; Veerabahu Shanmugasundaram; Michael M Hann; Pam J Thomas; Markus A Queisser; Andrew B Benowitz; Kris Brown; Andrew R Leach
Journal:  Nat Rev Drug Discov       Date:  2021-07-20       Impact factor: 84.694

4.  DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery.

Authors:  N J Kapolka; G J Taghon; J B Rowe; W M Morgan; J F Enten; N A Lambert; D G Isom
Journal:  Proc Natl Acad Sci U S A       Date:  2020-05-20       Impact factor: 11.205

5.  Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer.

Authors:  Amelia U Schirmer; Lucy M Driver; Megan T Zhao; Carrow I Wells; Julie E Pickett; Sean N O'Bryne; Benjamin J Eduful; Xuan Yang; Lauren Howard; Sungyong You; Gayathri R Devi; John DiGiovanni; Stephen J Freedland; Jen-Tsan Chi; David H Drewry; Everardo Macias
Journal:  Mol Ther       Date:  2021-08-25       Impact factor: 11.454

Review 6.  Phenotypic drug discovery: recent successes, lessons learned and new directions.

Authors:  Fabien Vincent; Arsenio Nueda; Jonathan Lee; Monica Schenone; Marco Prunotto; Mark Mercola
Journal:  Nat Rev Drug Discov       Date:  2022-05-30       Impact factor: 112.288

7.  How to Illuminate the Druggable Genome Using Pharos.

Authors:  Timothy Sheils; Stephen L Mathias; Vishal B Siramshetty; Giovanni Bocci; Cristian G Bologa; Jeremy J Yang; Anna Waller; Noel Southall; Dac-Trung Nguyen; Tudor I Oprea
Journal:  Curr Protoc Bioinformatics       Date:  2020-03

Review 8.  Therapies for rare diseases: therapeutic modalities, progress and challenges ahead.

Authors:  Erik Tambuyzer; Benjamin Vandendriessche; Christopher P Austin; Philip J Brooks; Kristina Larsson; Katherine I Miller Needleman; James Valentine; Kay Davies; Stephen C Groft; Robert Preti; Tudor I Oprea; Marco Prunotto
Journal:  Nat Rev Drug Discov       Date:  2019-12-13       Impact factor: 84.694

9.  KEA3: improved kinase enrichment analysis via data integration.

Authors:  Maxim V Kuleshov; Zhuorui Xie; Alexandra B K London; Janice Yang; John Erol Evangelista; Alexander Lachmann; Ingrid Shu; Denis Torre; Avi Ma'ayan
Journal:  Nucleic Acids Res       Date:  2021-07-02       Impact factor: 16.971

Review 10.  Recent advances in drug repurposing using machine learning.

Authors:  Fabio Urbina; Ana C Puhl; Sean Ekins
Journal:  Curr Opin Chem Biol       Date:  2021-07-16       Impact factor: 8.822
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