| Literature DB >> 29347826 |
Marie Preau1,2, Marjolaine Doumergue1, Christel Protiere2,3, Cécile Goujard4,5, Marion Mora2,3, Laurence Meyer5, Jean-Daniel Lelievre6, François Raffi7, Bruno Spire2,3, Olivier Lambotte4,8,9,10, Marie Suzan-Monti2,3.
Abstract
Essential HIV cure-related clinical trials (HCRCT) have a potentially high-risk profile in terms of participants' health, which could hinder enrollment by people living with HIV (PLWH) and healthcare professionals (HP). The ANRS-APSEC survey is part of the IAS "Towards an HIV cure" initiative, which promotes multidisciplinary research for a safe, affordable and scalable cure. The study objectives were to understand the psychosocial mechanisms underlying PLWH and HP viewpoints about future HCRCT. Six focus group discussions (three with PLWH (n = 21) and three with HP (n = 30)) were held in three French infectious disease units. From these, three perspectives on HCRCT were identified. The first involved beliefs and knowledge associating HCRCT with poorer health and quality of life for PLWH. The second concerned perceptions of HCRCT as a biological and epidemiological flashback to a situation when HIV infection was left uncontrolled. The third was characterized by aspects of historical HIV culture that embrace innovation.Entities:
Keywords: France; HIV history; Willingness to participate in clinical trials; cure trial
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Year: 2018 PMID： 29347826 DOI： 10.1080/09540121.2018.1426825
Source DB: PubMed Journal: AIDS Care ISSN： 0954-0121