Carol J Peden1, Michael G Mythen2,3, Thomas R Vetter4. 1. From the Department of Anesthesiology and Center for Health System Innovation, Keck School of Medicine, University of Southern California, Los Angeles, California. 2. Centre for Anaesthesia and Perioperative Medicine, University College London, London, England. 3. Department of Anesthesiology, Duke University, Durham, North Carolina. 4. Department of Surgery and Perioperative Care, Dell Medical School at the University of Texas at Austin, Austin, Texas.