Chaochao Tan1, Yupeng Wang1, Mingyue Lin1, Zhu Wang1, Li He1, Zhiyi Li1, Yu Li1, Keqian Xu2. 1. Department of Laboratory Medicine, Xiangya School of Medicine, Central South University, Changsha 410013, P.R. China. 2. Department of Laboratory Medicine, Xiangya School of Medicine, Central South University, Changsha 410013, P.R. China. Electronic address: xukeqian@csu.edu.cn.
Abstract
OBJECTIVE: To assess the adverse physiological changes induced by long-term exposure to PM2.5. METHODS: Totally 183 traffic policemen and 88 office policemen as the control group, were enrolled in this study. The concentrations of PM2.5 in both the working places of traffic and office policemen were obtained. Detailed personal questionnaires and conventional laboratory tests including hematology, fasting blood glucose, blood lipids, liver, kidney, immunity and tumor-related markers were conducted on all participants of this study. RESULTS: A dose-response relationship between the FBG, HDL-c and CEA values and the PM2.5 exposure duration was observed. Multivariate analysis confirmed that one hour on duty outdoor per day for one year was associated with an increase in FBG of 0.005% (95% CI: 0.0004% to 0.009%), CEA of 0.012% (95% CI: 0.006% to 0.017%), and a decrease in HDL-C of 0.001% (95% CI: 0.00034% to 0.002%). CONCLUSION: Long-term high air pollution exposure may lead to metabolism adaptation and it is likely involved in the development of cardiovascular disease and diabetes mellitus.
OBJECTIVE: To assess the adverse physiological changes induced by long-term exposure to PM2.5. METHODS: Totally 183 traffic policemen and 88 office policemen as the control group, were enrolled in this study. The concentrations of PM2.5 in both the working places of traffic and office policemen were obtained. Detailed personal questionnaires and conventional laboratory tests including hematology, fasting blood glucose, blood lipids, liver, kidney, immunity and tumor-related markers were conducted on all participants of this study. RESULTS: A dose-response relationship between the FBG, HDL-c and CEA values and the PM2.5 exposure duration was observed. Multivariate analysis confirmed that one hour on duty outdoor per day for one year was associated with an increase in FBG of 0.005% (95% CI: 0.0004% to 0.009%), CEA of 0.012% (95% CI: 0.006% to 0.017%), and a decrease in HDL-C of 0.001% (95% CI: 0.00034% to 0.002%). CONCLUSION: Long-term high air pollution exposure may lead to metabolism adaptation and it is likely involved in the development of cardiovascular disease and diabetes mellitus.
Authors: José C Vera-Jiménez; Marta Ferreiro-González; Gerardo F Barbero; José Ángel Álvarez; Francisco Fernández-Zacarías; Jesús Ayuso Journal: BMC Public Health Date: 2019-11-21 Impact factor: 3.295