| Literature DB >> 29345574 |
Jiayin Yang1,2, Xiaohong Liao3, Jerry Yu4, Ping Zhou1.
Abstract
CD73, also known as ecto-5'-nucleotidase (eN, NT5E, EC3.13.5), is the ratelimiting enzyme for adenosine generation and is expressed on multiple cells. Its expression is significantly influenced by hypoxia and inflammatory factors. During inflammation, CD73 protects endothelial barrier function and inhibits leukocyte trafficking. CD73 also promotes M2 macrophages (anti-inflammatory phenotype). In addition, CD73 is expressed on Treg cells and mediates immune suppression through adenosine. CD73 serves as an essential regulator for the immunity and inflammation. Its expression is related to many diseases, such as autoimmune diseases, ischemia-reperfusion injuries, arterial calcifications, and atherosclerosis. CD73 is overexpressed in many cancers. Its expression is positively associated with tumor growth, metastasis, angiogenesis, poor prognosis and resistance to chemotherapy. Thus, CD73 may be used for prognostic indicator and therapeutic target in diseases such as cancers. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.Entities:
Keywords: CD73; cancer; disease; ecto-5'-nucleotidase; immunity; inflammation.
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Year: 2018 PMID： 29345574 DOI： 10.2174/0929867325666180117101114
Source DB: PubMed Journal: Curr Med Chem ISSN： 0929-8673 Impact factor: 4.530