Barbara Wensing1, Manabu Mochizuki2,3, Joke H De Boer4. 1. a Oogcentrum Noord Holland , Heerhugowaard , The Netherlands. 2. b Department of Ophthalmology and Visual Science , Tokyo Medical and Dental University , Tokyo , Japan. 3. c Miyata Eye Hospital , Miyakonojo , Japan. 4. d Department of Ophthalmology , University Medical Center , Utrecht , The Netherlands.
Abstract
PURPOSE: The aim of this study is to describe the clinical characteristics of molecularly proven Herpes simplex virus (HSV) anterior uveitis. METHODS: The literature on HSV anterior uveitis whereby the diagnosis was confirmed by polymerase chain reaction (PCR) and or Goldmann-Witmer coefficient in aqueous humor was reviewed. Three studies from Europe and one from Japan could be included. RESULTS: It was observed that HSV anterior uveitis is mostly an acute unilateral disease mainly occurring in middle-aged people with a predominance in females. The incidence of keratitis in HSV is between 33 and 41%. High intraocular pressure is frequently observed and ranged from 46 to 90%. Sectorial iris atrophy may be absent, especially early in the disease. CONCLUSION: The clinical characteristics of HSV anterior uveitis can mimic other viral and non-infectious anterior uveitis entities especially at onset. Aqueous humor analysis for PCR and GWC can be useful in case of suspected viral uveitis.
PURPOSE: The aim of this study is to describe the clinical characteristics of molecularly proven Herpes simplex virus (HSV) anterior uveitis. METHODS: The literature on HSV anterior uveitis whereby the diagnosis was confirmed by polymerase chain reaction (PCR) and or Goldmann-Witmer coefficient in aqueous humor was reviewed. Three studies from Europe and one from Japan could be included. RESULTS: It was observed that HSV anterior uveitis is mostly an acute unilateral disease mainly occurring in middle-aged people with a predominance in females. The incidence of keratitis in HSV is between 33 and 41%. High intraocular pressure is frequently observed and ranged from 46 to 90%. Sectorial iris atrophy may be absent, especially early in the disease. CONCLUSION: The clinical characteristics of HSV anterior uveitis can mimic other viral and non-infectious anterior uveitis entities especially at onset. Aqueous humor analysis for PCR and GWC can be useful in case of suspected viral uveitis.
Authors: Hung-Jui Hsu; Chia-Yi Lee; Kun-Lin Yang; Hung-Chi Chen; Chi-Chin Sun; Jing-Yang Huang; Hung-Yu Lin; Shun-Fa Yang Journal: Int J Environ Res Public Health Date: 2019-04-05 Impact factor: 3.390