Literature DB >> 29344675

Expression and prognostic significance of TRPV6 in the development and progression of pancreatic cancer.

He Song1, Ming Dong1, Jianping Zhou1, Weiwei Sheng1, Xin Li1, Wei Gao1.   

Abstract

In this study, we aimed to clarify the expression and biological functions of TRPV6 in human pancreatic cancer (PC) tissue and pancreatic cancer (PC) cell lines. TRPV6 was up-regulated in the primary cancer tissues from pancreatic cancer (PC) patients. TRPV6 may regulate multiple proteins related to apoptosis, cell cycle and metastasis pathways. Silencing TRPV6 significantly inhibited invasion, proliferation and migration and induced apoptosis and cell cycle arrest. TRPV6 plays a promising role of an oncogene in pancreatic carcinogenesis and represents the new potential biomarker for PC.

Entities:  

Mesh：

Substances：

Year:  2018        PMID： 29344675     DOI： 10.3892/or.2018.6216

Source DB:  PubMed          Journal:  Oncol Rep        ISSN： 1021-335X            Impact factor:   4.136


  19 in total

Review 1.  Calcium selective channel TRPV6: Structure, function, and implications in health and disease.

Authors:  Vinayak Khattar; Lingyun Wang; Ji-Bin Peng
Journal:  Gene       Date:  2022-01-11       Impact factor: 3.688

Review 2.  TRP Channels as Molecular Targets to Relieve Endocrine-Related Diseases.

Authors:  Yusheng Liu; Yihan Lyu; Hongmei Wang
Journal:  Front Mol Biosci       Date:  2022-04-28

Review 3.  Ca2+ Signalling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression.

Authors:  Madelaine Magalì Audero; Natalia Prevarskaya; Alessandra Fiorio Pla
Journal:  Int J Mol Sci       Date:  2022-07-02       Impact factor: 6.208

4.  TRPV6 Regulation by Cis-22a and Cholesterol.

Authors:  Christina Humer; Sonja Lindinger; Aline L Carrel; Christoph Romanin; Carmen Höglinger
Journal:  Biomolecules       Date:  2022-06-08

Review 5.  Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression.

Authors:  Gonçalo Mesquita; Natalia Prevarskaya; Albrecht Schwab; V'yacheslav Lehen'kyi
Journal:  Cells       Date:  2021-04-26       Impact factor: 6.600

6.  Inhibition of Transient Receptor Potential Vanilloid 6 channel, elevated in human ovarian cancers, reduces tumour growth in a xenograft model.

Authors:  Hui Xue; Yuzhuo Wang; Tyson J MacCormack; Tyler Lutes; Christopher Rice; Michelle Davey; Dominique Dugourd; T Toney Ilenchuk; John M Stewart
Journal:  J Cancer       Date:  2018-08-06       Impact factor: 4.207

7.  TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer.

Authors:  María Paz Saldías; Diego Maureira; Octavio Orellana-Serradell; Ian Silva; Boris Lavanderos; Pablo Cruz; Camila Torres; Mónica Cáceres; Oscar Cerda
Journal:  Front Oncol       Date:  2021-06-10       Impact factor: 6.244

8.  RNA interference mediated suppression of TRPV6 inhibits the progression of prostate cancer in vitro by modulating cathepsin B and MMP9 expression.

Authors:  Duk Yoon Kim; Soon Hee Kim; Eun Kyoung Yang
Journal:  Investig Clin Urol       Date:  2021-05-20

Review 9.  The Role of TRP Channels in the Metastatic Cascade.

Authors:  Benedikt Fels; Etmar Bulk; Zoltán Pethő; Albrecht Schwab
Journal:  Pharmaceuticals (Basel)       Date:  2018-05-17

10.  TRPV6 calcium channel directs homeostasis of the mammary epithelial sheets and controls epithelial mesenchymal transition.

Authors:  Tytti Kärki; Eeva Kaisa Rajakylä; Anna Acheva; Sari Tojkander
Journal:  Sci Rep       Date:  2020-09-07       Impact factor: 4.379
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.